IGFBP6

IGFBP6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RMJ
Identifiers
Aliases	IGFBP6, IBP6, insulin like growth factor binding protein 6
External IDs	OMIM: 146735; MGI: 96441; HomoloGene: 1641; GeneCards: IGFBP6; OMA:IGFBP6 - orthologs
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 F2 Start 102,052,797 bp End 102,057,946 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon tibial nerve gastric mucosa canal of the cervix left uterine tube right coronary artery thoracic aorta ascending aorta trigeminal ganglion left coronary artery Top expressed in ankle uterus right lung right lung lobe ankle joint cervix left lung lip white adipose tissue esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function insulin-like growth factor binding signaling receptor binding growth factor binding insulin-like growth factor I binding insulin-like growth factor II binding fibronectin binding Cellular component cytoplasm Golgi apparatus extracellular region extracellular space insulin-like growth factor binary complex Biological process regulation of insulin-like growth factor receptor signaling pathway negative regulation of canonical Wnt signaling pathway regulation of cell growth signal transduction negative regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3489 16012 Ensembl n/a ENSMUSG00000023046 UniProt P24592 P47880 RefSeq (mRNA) NM_002178 NM_008344 RefSeq (protein) NP_002169 NP_032370 Location (UCSC) n/a Chr 15: 102.05 – 102.06 Mb PubMed search
Wikidata
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Insulin-like growth factor-binding protein 6 (IGFBP-6) is a protein that in humans is encoded by the IGFBP6 gene.

Further reading

• Wood AW, Duan C, Bern HA (2005). "Insulin-like growth factor signaling in fish". Int. Rev. Cytol. International Review of Cytology. 243: 215–85. doi:10.1016/S0074-7696(05)43004-1. ISBN 9780123646477. PMID 15797461.
• Zapf J, Kiefer M, Merryweather J, et al. (1990). "Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia". J. Biol. Chem. 265 (25): 14892–8. doi:10.1016/S0021-9258(18)77200-1. PMID 1697583.
• Kiefer MC, Masiarz FR, Bauer DM, Zapf J (1991). "Identification and molecular cloning of two new 30-kDa insulin-like growth factor binding proteins isolated from adult human serum". J. Biol. Chem. 266 (14): 9043–9. doi:10.1016/S0021-9258(18)31549-7. PMID 1709161.
• Shimasaki S, Gao L, Shimonaka M, Ling N (1991). "Isolation and molecular cloning of insulin-like growth factor-binding protein-6". Mol. Endocrinol. 5 (7): 938–48. doi:10.1210/mend-5-7-938. PMID 1719383.
• Andress DL, Birnbaum RS (1991). "A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells". Biochem. Biophys. Res. Commun. 176 (1): 213–8. doi:10.1016/0006-291X(91)90911-P. PMID 1850257.
• Martin JL, Willetts KE, Baxter RC (1990). "Purification and properties of a novel insulin-like growth factor-II binding protein from transformed human fibroblasts". J. Biol. Chem. 265 (7): 4124–30. doi:10.1016/S0021-9258(19)39711-X. PMID 2154495.
• Roghani M, Hossenlopp P, Lepage P, et al. (1989). "Isolation from human cerebrospinal fluid of a new insulin-like growth factor-binding protein with a selective affinity for IGF-II". FEBS Lett. 255 (2): 253–8. doi:10.1016/0014-5793(89)81101-9. PMID 2551732. S2CID 22982971.
• Ilvesmäki V, Blum WF, Voutilainen R (1994). "Insulin-like growth factor binding proteins in the human adrenal gland". Mol. Cell. Endocrinol. 97 (1–2): 71–9. doi:10.1016/0303-7207(93)90212-3. PMID 7511544. S2CID 22503525.
• Kato M, Ishizaki A, Hellman U, et al. (1995). "A human keratinocyte cell line produces two autocrine growth inhibitors, transforming growth factor-beta and insulin-like growth factor binding protein-6, in a calcium- and cell density-dependent manner". J. Biol. Chem. 270 (21): 12373–9. doi:10.1074/jbc.270.21.12373. PMID 7539002.
• Delhanty PJ, Hill DJ, Shimasaki S, Han VK (1993). "Insulin-like growth factor binding protein-4, -5 and -6 mRNAs in the human fetus: localization to sites of growth and differentiation?". Growth Regul. 3 (1): 8–11. PMID 7683540.
• Bach LA, Hsieh S, Sakano K, et al. (1993). "Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6". J. Biol. Chem. 268 (13): 9246–54. doi:10.1016/S0021-9258(18)98342-0. PMID 7683646.
• Wegmann BR, Schöneberger HJ, Kiefer PE, et al. (1993). "Molecular cloning of IGFBP-5 from SCLC cell lines and expression of IGFBP-4, IGFBP-5 and IGFBP-6 in lung cancer cell lines and primary tumours". Eur. J. Cancer. 29A (11): 1578–84. doi:10.1016/0959-8049(93)90298-T. PMID 7692907.
• Neumann GM, Marinaro JA, Bach LA (1998). "Identification of O-glycosylation sites and partial characterization of carbohydrate structure and disulfide linkages of human insulin-like growth factor binding protein 6". Biochemistry. 37 (18): 6572–85. doi:10.1021/bi972894e. PMID 9572875.
• Neumann GM, Bach LA (1999). "The N-terminal disulfide linkages of human insulin-like growth factor-binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometry". J. Biol. Chem. 274 (21): 14587–94. doi:10.1074/jbc.274.21.14587. PMID 10329650.
• Wong MS, Fong CC, Yang M (1999). "Biosensor measurement of the interaction kinetics between insulin-like growth factors and their binding proteins". Biochim. Biophys. Acta. 1432 (2): 293–301. doi:10.1016/S0167-4838(99)00106-5. PMID 10407151.
• Yu H, Mistry J, Nicar MJ, et al. (1999). "Insulin-like growth factors (IGF-I, free IGF-I and IGF-II) and insulin-like growth factor binding proteins (IGFBP-2, IGFBP-3, IGFBP-6, and ALS) in blood circulation". J. Clin. Lab. Anal. 13 (4): 166–72. doi:10.1002/(SICI)1098-2825(1999)13:4<166::AID-JCLA5>3.0.CO;2-X. PMC 6808158. PMID 10414596.
• Dailly YP, Zhou Y, Linkhart TA, et al. (2001). "Structure and characterization of the human insulin-like growth factor binding protein (IGFBP)-6 promoter: identification of a functional retinoid response element". Biochim. Biophys. Acta. 1518 (1–2): 145–51. doi:10.1016/S0167-4781(01)00192-0. PMID 11267670.
• Weinzimer SA, Gibson TB, Collett-Solberg PF, et al. (2001). "Transferrin is an insulin-like growth factor-binding protein-3 binding protein". J. Clin. Endocrinol. Metab. 86 (4): 1806–13. doi:10.1210/jcem.86.4.7380. PMID 11297622.