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Glutathione amide-dependent peroxidase

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Glutathione amide-dependent peroxidase
Identifiers
EC no.1.11.1.17
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IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
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MetaCycmetabolic pathway
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Glutathione amide-dependent peroxidase (EC 1.11.1.17) is an enzyme with systematic name glutathione amide:hydrogen-peroxide oxidoreductase.[1] This enzyme catalyses the following chemical reaction

2 glutathione amide + H2O2 glutathione amide disulfide + 2 H2O

This enzyme from the proteobacterium Marichromatium gracile is a chimeric protein. It contains a peroxiredoxin-like N-terminus and a glutaredoxin-like C terminus.

References

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  1. ^ Vergauwen B, Pauwels F, Jacquemotte F, Meyer TE, Cusanovich MA, Bartsch RG, Van Beeumen JJ (June 2001). "Characterization of glutathione amide reductase from Chromatium gracile. Identification of a novel thiol peroxidase (Prx/Grx) fueled by glutathione amide redox cycling". The Journal of Biological Chemistry. 276 (24): 20890–7. doi:10.1074/jbc.M102026200. PMID 11399772.
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