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Protein-coding gene in the species Homo sapiens
Gem-associated protein 5 is a protein that in humans is encoded by the GEMIN5 gene .[ 5] [ 6]
Gem-associated protein 5 is part of the SMN a large protein complex localized to both the cytoplasm and the nucleus that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), gem-associated protein 2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), and GEMIN4 (MIM 606969).[ 6]
GEMIN5 has been shown to interact with DDX20 [ 5] [ 7] SMN1 .[ 5]
^ a b c GRCh38: Ensembl release 89: ENSG00000082516 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037275 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b c Gubitz AK, Mourelatos Z, Abel L, Rappsilber J , Mann M, Dreyfuss G (Feb 2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins" . J Biol Chem . 277 (7): 5631–6. doi :10.1074/jbc.M109448200 PMID 11714716 . ^ a b "Entrez Gene: GEMIN5 gem (nuclear organelle) associated protein 5" .^ Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs" . Genes Dev . 16 (6): 720–8. doi :10.1101/gad.974702 . PMC 155365 PMID 11914277 .
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