Nucleoporin 35

NUP35
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4LIR
Identifiers
Aliases	NUP35, MP-44, MP44, NP44, NUP53, nucleoporin 35kDa, nucleoporin 35
External IDs	OMIM: 608140; MGI: 1916732; HomoloGene: 44517; GeneCards: NUP35; OMA:NUP35 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q32.1 Start 183,117,513 bp End 183,161,680 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 C3 Start 80,447,580 bp End 80,489,250 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte sperm ventricular zone pancreatic epithelial cell gonad Achilles tendon cartilage tissue islet of Langerhans ganglionic eminence Top expressed in secondary oocyte zygote primary oocyte morula yolk sac epiblast tail of embryo genital tubercle embryo embryo More reference expression data BioGPS n/a
Gene ontology Molecular function single-stranded DNA binding protein binding phospholipid binding nucleic acid binding structural constituent of nuclear pore Cellular component nuclear lamina nuclear membrane nuclear envelope membrane plasma membrane nuclear pore nucleoplasm nuclear pore central transport channel nuclear pore nuclear basket nucleus host cell Biological process mRNA transport regulation of transcription, DNA-templated protein transport viral process nuclear pore organization NLS-bearing protein import into nucleus mRNA export from nucleus nucleocytoplasmic transport regulation of glycolytic process tRNA export from nucleus protein sumoylation viral transcription regulation of gene silencing by miRNA intracellular transport of virus regulation of cellular response to heat Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 129401 69482 Ensembl ENSG00000163002 ENSMUSG00000026999 UniProt Q8NFH5 Q8R4R6 RefSeq (mRNA) NM_001008544 NM_001287584 NM_001287585 NM_138285 NM_001190179 NM_027091 RefSeq (protein) NP_001274513 NP_001274514 NP_612142 NP_001177108 NP_081367 Location (UCSC) Chr 2: 183.12 – 183.16 Mb Chr 2: 80.45 – 80.49 Mb PubMed search
Wikidata
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Nucleoporin 35 (Nup35) is a protein that in humans is encoded by the NUP35 gene.

Background

This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is part of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC.

Further reading

• Rodenas E, Klerkx EP, Ayuso C, Audhya A, Askjaer P (2009). "Early embryonic requirement for nucleoporin Nup35/NPP-19 in nuclear assembly". Developmental Biology. 327 (2): 399–409. doi:10.1016/j.ydbio.2008.12.024. hdl:10261/17735. PMID 19146848. S2CID 13344975.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Mansfeld J, Güttinger S, Hawryluk-Gara LA, et al. (2006). "The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells". Mol. Cell. 22 (1): 93–103. doi:10.1016/j.molcel.2006.02.015. PMID 16600873.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
• Hawryluk-Gara LA, Shibuya EK, Wozniak RW (2005). "Vertebrate Nup53 Interacts with the Nuclear Lamina and Is Required for the Assembly of a Nup93-containing Complex". Mol. Biol. Cell. 16 (5): 2382–94. doi:10.1091/mbc.E04-10-0857. PMC 1087243. PMID 15703211.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cronshaw JM, Krutchinsky AN, Zhang W, et al. (2002). "Proteomic analysis of the mammalian nuclear pore complex". J. Cell Biol. 158 (5): 915–27. doi:10.1083/jcb.200206106. PMC 2173148. PMID 12196509.

External links

• Overview of all the structural information available in the PDB for UniProt: Q8NFH5 (Human Nucleoporin NUP35) at the PDBe-KB.