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Draft:Greg Neely

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  • Comment: Wikipedia articles should be written neutrally, not try to promote someone. QuicoleJR (talk) 19:37, 6 January 2025 (UTC)
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Greg Neely
Greg Neely at a conference in 2024
Professor Greg Neely, pictured at a conference in 2024
Born(1974-11-05)November 5, 1974
Toronto, Canada
NationalityCanadian-Australian
Alma materUniversity of Calgary
Scientific career
FieldsFunctional genomics, Pain, Neuroscience, Immunology
InstitutionsInstitute of Molecular Biotechnology, Garvan Institute of Medical Research, University of Sydney

Greg Neely is a prominent Canadian-Australian scientist specialising in functional genomics. He is Head of the Dr. John and Anne Chong Lab at the Charles Perkins Centre, University of Sydney. He was the first to show neuropathic pain-like behaviour in insects.[1], the molecular basis of synesthesia [2], and developed new antidotes to venoms from cobra snakes [3] and box jellyfish [4].

Early life and education

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Neely was born in Toronto, Canada and pursued his higher education at the University of Calgary. He earned a Bachelor of Science in Cellular, Molecular and Microbial Biology in 1997, followed by a PhD in Cellular Immunology under Christopher H. Mody [5]. This was funded by the Loraine Award and focused on immunological mechanisms at the cellular level [6][7].

Career

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After completing a postdoctoral fellowship in Austria (2003-10) with Josef Penninger [8] at the Institute of Molecular Biotechnology [9], Neely joined the Garvan Institute of Medical Research [10] in Sydney as a Faculty and Principal Research Fellow (2010-2015). In 2015, he moved to the University of Sydney [11], where he has continued his research into genomics and pain at the Charles Perkins Centre [12]

Research and discoveries

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Neely's research program uses functional genomics to identify core molecular mechanisms that govern physiological systems. His laboratory was the first to set up whole-genome CRISPR screening in Australia.

His primary research focus is chronic pain. He has identified hundreds of new pain genes [2], including TRPA1, an ancient pain receptor conserved across species [13]. Neely demonstrated that insects can experience something like neuropathic pain [1], suggesting evolutionary conservation of pain responses. His research also contributed to understanding synesthesia by identifying molecular pathways linking sensory inputs [2].

In venom research, Neely's team developed new antidotes for cobra [3] and box jellyfish [4] venoms, using CRISPR screening to identify pathways targeted by repurposed drugs.

During the COVID-19 pandemic, Neely's group identified LRRC15, a lung protein that may provide protection against SARS-CoV-2, offering potential avenues for treatment [14]. His lab also investigated artificial sweeteners' effects on metabolism, showing links between sucralose and increased food intake in fruit flies [15] [16][17].

Awards and recognition

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Neely has received several prestigious awards, including multiple NHMRC Career Development Fellowships and the NHMRC Marshall and Warren Award for innovative research [18]. His research has been featured in major media outlets like the BBC [19][20], CNN [21], The Guardian [22][23], France 24 [24], Sydney Morning Herald [25][26], Scientific American [27], The Lancet [28], Science [29][30] and Nature [31][32].

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References

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  1. ^ a b Khuong, TM (2019). "Nerve injury drives a heightened state of vigilance and neuropathic sensitization in Drosophila". Science Advances. 5 (7): eaaw4099. Bibcode:2019SciA....5.4099K. doi:10.1126/sciadv.aaw4099. PMC 6620091. PMID 31309148.
  2. ^ a b c Neely, GG (2010). "A Genome-wide Drosophila Screen for Heat Nociception Identifies α2δ3 as an Evolutionarily Conserved Pain Gene". Cell. 143 (4): 628–638. doi:10.1016/j.cell.2010.09.047. PMC 3040441. PMID 21074052.
  3. ^ a b Du, TY (2024). "Molecular dissection of cobra venom highlights heparinoids as an antidote for spitting cobra envenoming". Science Translational Medicine. 16 (756): eadk4802. doi:10.1126/scitranslmed.adk4802. PMID 39018365.
  4. ^ a b Lau, MT (2019). "Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote". Nature Communications. 10 (1): 1655. Bibcode:2019NatCo..10.1655L. doi:10.1038/s41467-019-09681-1. PMC 6491561. PMID 31040274.
  5. ^ Mody, Christopher (27 January 2020). "Professor". University of Calgary.
  6. ^ Neely, GG (2004). "Monocyte Surface-Bound IL-15 Can Function as an Activating Receptor and Participate in Reverse Signaling". Journal of Immunology. 172 (7): 4225–4234. doi:10.4049/jimmunol.172.7.4225. PMID 15034035.
  7. ^ Neely, GG (2001). "Lipopolysaccharide-Stimulated or Granulocyte-Macrophage Colony-Stimulating Factor-Stimulated Monocytes Rapidly Express Biologically Active IL-15 on Their Cell Surface Independent of New Protein Synthesis". Journal of Immunology. 167 (9): 5011–5017. doi:10.4049/jimmunol.167.9.5011. PMID 11673509.
  8. ^ Penninger, Joseph. "Professor". Institute of Molecular Biotechnology, of the Austrian Academy of Sciences.
  9. ^ "Institute of Molecular Biotechnology, of the Austrian Academy of Sciences".
  10. ^ "Garvan Institute of Medical Research".
  11. ^ "University of Sydney".
  12. ^ "Charles Perkins Centre, University of Sydney".
  13. ^ Neely, GG (2011). "TrpA1 Regulates Thermal Nociception in Drosophila". PLOS ONE. 6 (8): e24343. Bibcode:2011PLoSO...624343N. doi:10.1371/journal.pone.0024343. PMC 3164203. PMID 21909389.
  14. ^ Loo, L (2023). "Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs". PLOS Biology. 21 (2): e3001967. doi:10.1371/journal.pbio.3001967. PMC 9910744. PMID 36757924.
  15. ^ Wang, QP (2016). "Sucralose Promotes Food Intake through NPY and a Neuronal Fasting Response". Cell Metabolism. 24 (1): 75–90. doi:10.1016/j.cmet.2016.06.010. PMID 27411010.
  16. ^ Wang, QP (2017). "Chronic Sucralose or L-Glucose Ingestion Does Not Suppress Food Intake". Cell Metabolism. 26 (2): 279–280. doi:10.1016/j.cmet.2017.07.002. PMID 28768164.
  17. ^ Wang, QP (2018). "Non-nutritive sweeteners possess a bacteriostatic effect and alter gut microbiota in mice". PLOS ONE. 13 (7): e0199080. Bibcode:2018PLoSO..1399080W. doi:10.1371/journal.pone.0199080. PMC 6033410. PMID 29975731.
  18. ^ "NHMRC Marshall and Warren Ideas Grant (Innovation) Awards".
  19. ^ "BBC article".
  20. ^ "BBC article, 2016". BBC News. 13 July 2016.
  21. ^ "CNN article". May 2019.
  22. ^ Zhou, Naaman (20 July 2019). "The Guardian, article". TheGuardian.com.
  23. ^ Davey, Melissa (9 February 2023). "The Guardian, article, 2023". TheGuardian.com.
  24. ^ "France 24 article, 2019". May 2019.
  25. ^ "The end of venom? Sydney scientists find new cure for flesh-eating snake bites". Sydney Morning Herald. 17 July 2024.
  26. ^ "Curing cancer, designer babies, supersoldiers: How will gene-editing change us?". Sydney Morning Herald. 4 July 2021.
  27. ^ "Scientific American article, 2016". Scientific American.
  28. ^ "The Lancet, article, 2023" (PDF).
  29. ^ "Science".
  30. ^ "Science article".
  31. ^ Willyard, Cassandra (21 November 2024). "Nature article". Nature. doi:10.1038/d41586-024-03818-z. PMID 39572669.
  32. ^ "Nature article, 2016". Nature. 535 (7611): 203. July 2016. doi:10.1038/535203e.
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