D-lysopine dehydrogenase
| D-lysopine dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.5.1.16 | ||||||||
| CAS no. | 65187-41-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a D-lysopine dehydrogenase (EC 1.5.1.16) is an enzyme that catalyzes the chemical reaction
- N2-(D-1-carboxyethyl)-L-lysine + NADP+ + H2O L-lysine + pyruvate + NADPH + H+
The 3 substrates of this enzyme are N2-(D-1-carboxyethyl)-L-lysine, NADP+, and H2O, whereas its 4 products are L-lysine, pyruvate, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is N2-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming). Other names in common use include D-lysopine synthase, lysopine dehydrogenase, D(+)-lysopine dehydrogenase, 2-N-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase, and (L-lysine-forming). This enzyme participates in lysine degradation.
References
[edit]- Otten LA, Vreugdenhil D, Schilperoort RA (1977). "Properties of D(+)-lysopine dehydrogenase from crown gall tumour tissue". Biochim. Biophys. Acta. 485 (2): 268–77. doi:10.1016/0005-2744(77)90163-2. PMID 21695.
