Chromatin assembly factor I (CAF-1) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair.[7]
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Shim KS, Bergelson JM, Furuse M, Ovod V, Krude T, Lubec G (2003). "Reduction of chromatin assembly factor 1 p60 and C21orf2 protein, encoded on chromosome 21, in Down Syndrome brain". Advances in Down Syndrome Research. Journal of Neural Transmission Supplement 67. Vol. 67. pp. 117–28. doi:10.1007/978-3-7091-6721-2_10. ISBN978-3-211-40776-9. PMID15068244. {{cite book}}: |journal= ignored (help)
