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Protein-coding gene in the species Homo sapiens
Histone chaperone ASF1A is a protein that in humans is encoded by the ASF1A gene .[ 5] [ 6] [ 7]
This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair.[ 7]
ASF1A has been shown to interact with TLK1 ,[ 8] [ 9] TLK2 ,[ 8] CHAF1B [ 10] CHAF1A .[ 10]
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PDB gallery
1tey : NMR structure of human histone chaperone, ASF1A
2i32 : Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly
2iij : Structure of human Asf1a in complex with histone H3
2io5 : Crystal structure of the CIA- histone H3-H4 complex
