From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Cell migration-inducing and hyaluronan -binding protein (CEMIP ), formerly known as KIAA1199 , is a protein that in humans is encoded by the CEMIP gene .[ 5] hyaluronic acid and catalyze its depolymerization independently of CD44 and hyaluronidases .[ 6] [ 7]
CEMIP is associated with nonsyndromic deafness ,[ 8] cancers .[ 9]
^ a b c GRCh38: Ensembl release 89: ENSG00000103888 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052353 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: KIAA1199 KIAA1199" .^ Yoshida H, Nagaoka A, Kusaka-Kikushima A, Tobiishi M, Kawabata K, Sayo T, Sakai S, Sugiyama Y, Enomoto H, Okada Y, Inoue S (18 March 2013). "KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization" . Proceedings of the National Academy of Sciences . 110 (14): 5612–5617. Bibcode :2013PNAS..110.5612Y . doi :10.1073/pnas.1215432110 PMC 3619336 PMID 23509262 . ^ Yoshida H, Nagaoka A, Nakamura S, Sugiyama Y, Okada Y, Inoue S (17 August 2013). "Murine homologue of the human KIAA1199 is implicated in hyaluronan binding and depolymerization" . FEBS Open Bio . 3 (1): 352–356. doi :10.1016/j.fob.2013.08.003 . PMC 3821019 PMID 24251095 . ^ Abe S, Usami S, Nakamura Y (Nov 2003). "Mutations in the gene encoding KIAA1199 protein, an inner-ear protein expressed in Deiters' cells and the fibrocytes, as the cause of nonsyndromic hearing loss" . J Hum Genet . 48 (11): 564–70. doi :10.1007/s10038-003-0079-2 PMID 14577002 . ^ Zhang Y, Jia S, Jiang W (20 February 2014). "KIAA1199 and its biological role in human cancer and cancer cells (Review)" . Oncology Reports . 31 (4): 1503–1508. doi :10.3892/or.2014.3038 PMID 24573670 .
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