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CDKN2C

From Wikipedia, the free encyclopedia
CDKN2C
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCDKN2C, INK4C, p18, p18-INK4C, cyclin-dependent kinase inhibitor 2C, cyclin dependent kinase inhibitor 2C
External IDsOMIM: 603369; MGI: 105388; HomoloGene: 966; GeneCards: CDKN2C; OMA:CDKN2C - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_078626
NM_001262

NM_001301368
NM_007671

RefSeq (protein)

NP_001253
NP_523240

NP_001288297
NP_031697

Location (UCSC)Chr 1: 50.96 – 50.97 MbChr 4: 109.52 – 109.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cyclin-dependent kinase 4 inhibitor C is an enzyme that in humans is encoded by the CDKN2C gene.[5][6][7]

Function

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The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.[7]

Interactions

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CDKN2C has been shown to interact with Cyclin-dependent kinase 4[5][8] and Cyclin-dependent kinase 6.[5][8][9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123080Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028551Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c Guan KL, Jenkins CW, Li Y, Nichols MA, Wu X, O'Keefe CL, Matera AG, Xiong Y (January 1995). "Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function". Genes Dev. 8 (24): 2939–52. doi:10.1101/gad.8.24.2939. PMID 8001816.
  6. ^ Blais A, Labrie Y, Pouliot F, Lachance Y, Labrie C (July 1998). "Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer". Biochem. Biophys. Res. Commun. 247 (1): 146–53. doi:10.1006/bbrc.1998.8497. PMID 9636670. S2CID 38236434.
  7. ^ a b "Entrez Gene: CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)".
  8. ^ a b Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  9. ^ Jeffrey PD, Tong L, Pavletich NP (December 2000). "Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors". Genes Dev. 14 (24): 3115–25. doi:10.1101/gad.851100. PMC 317144. PMID 11124804.

Further reading

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