CDKN2B

CDKN2B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1D9S
Identifiers
Aliases	CDKN2B, CDK4I, INK4B, MTS2, P15, TP15, p15INK4b, cyclin-dependent kinase inhibitor 2B, cyclin dependent kinase inhibitor 2B
External IDs	OMIM: 600431; MGI: 104737; HomoloGene: 55859; GeneCards: CDKN2B; OMA:CDKN2B - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	22,009,305 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	89,229,276 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; mucosa of colon; ; mucosa of sigmoid colon; ; oral cavity; ; mucosa of transverse colon; ; rectum; ; buccal mucosa cell; ; duodenum; ; skin of hip; ; gums;
	Top expressed in
	epithelium of stomach; ; jejunum; ; left colon; ; calvaria; ; ileum; ; endothelial cell of lymphatic vessel; ; mucous cell of stomach; ; transitional epithelium of urinary bladder; ; right lung lobe; ; conjunctival fornix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; cyclin-dependent protein serine/threonine kinase inhibitor activity; protein kinase binding;
Cellular component	cytoplasm; cytosol; nucleus;
Biological process	cellular response to extracellular stimulus; megakaryocyte differentiation; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of cyclin-dependent protein serine/threonine kinase activity; mitotic cell cycle checkpoint signaling; spleen development; cellular response to nutrient; negative regulation of G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; negative regulation of epithelial cell proliferation; cell cycle; negative regulation of phosphorylation; positive regulation of transcription by RNA polymerase II; negative regulation of cell population proliferation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; cellular senescence;
	Sources:Amigo / QuickGO
Orthologs
	1030
	12579
	ENSG00000147883
	ENSMUSG00000073802
	P42772
	P55271
	NM_078487; NM_004936
	NM_007670
	NP_004927; NP_511042
	NP_031696
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin-dependent kinase 4 inhibitor B also known as multiple tumor suppressor 2 (MTS-2) or p15^INK4b is a protein that is encoded by the CDKN2B gene in humans.^[5]^[6]

Function

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated, deleted, or disregulated in a wide variety of cancer.^[7]^[8]^[9] This gene encodes a cyclin-dependent kinase inhibitor, also known as p15Ink4b protein, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases by cyclin D, thus the encoded protein functions as a cell growth regulator that inhibits cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcripts of this gene encode proteins that share the N-terminal sequence but completely differ in the C-terminus.^[6]

Interactions

CDKN2B tumor suppressor gene product p15 has been shown to interact with cyclin-dependent kinase 4.^[10]^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147883 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000073802 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hannon GJ, Beach D (September 1994). "p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest". Nature. 371 (6494): 257–61. Bibcode:1994Natur.371..257H. doi:10.1038/371257a0. PMID 8078588. S2CID 4268054.
^ ^a ^b "Entrez Gene: CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)".
^ Tu Q, Hao J, Zhou X, Yan L, Dai H, Sun B, et al. (January 2018). "CDKN2B deletion is essential for pancreatic cancer development instead of unmeaningful co-deletion due to juxtaposition to CDKN2A". Oncogene. 37 (1): 128–138. doi:10.1038/onc.2017.316. PMC 5759028. PMID 28892048.
^ Jafri M, Wake NC, Ascher DB, Pires DE, Gentle D, Morris MR, et al. (July 2015). "Germline Mutations in the CDKN2B Tumor Suppressor Gene Predispose to Renal Cell Carcinoma". Cancer Discovery. 5 (7): 723–9. doi:10.1158/2159-8290.CD-14-1096. PMID 25873077.
^ Yu W, Gius D, Onyango P, Muldoon-Jacobs K, Karp J, Feinberg AP, Cui H (January 2008). "Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA". Nature. 451 (7175): 202–6. Bibcode:2008Natur.451..202Y. doi:10.1038/nature06468. PMC 2743558. PMID 18185590.
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
^ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, et al. (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.

External links

CDKN2B human gene location in the UCSC Genome Browser.
CDKN2B human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000147883 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000073802 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8078588-5] Hannon GJ, Beach D (September 1994). "p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest". Nature. 371 (6494): 257–61. Bibcode:1994Natur.371..257H. doi:10.1038/371257a0. PMID 8078588. S2CID 4268054.

[entrez-6] "Entrez Gene: CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)".

[7] Tu Q, Hao J, Zhou X, Yan L, Dai H, Sun B, et al. (January 2018). "CDKN2B deletion is essential for pancreatic cancer development instead of unmeaningful co-deletion due to juxtaposition to CDKN2A". Oncogene. 37 (1): 128–138. doi:10.1038/onc.2017.316. PMC 5759028. PMID 28892048.

[8] Jafri M, Wake NC, Ascher DB, Pires DE, Gentle D, Morris MR, et al. (July 2015). "Germline Mutations in the CDKN2B Tumor Suppressor Gene Predispose to Renal Cell Carcinoma". Cancer Discovery. 5 (7): 723–9. doi:10.1158/2159-8290.CD-14-1096. PMID 25873077.

[9] Yu W, Gius D, Onyango P, Muldoon-Jacobs K, Karp J, Feinberg AP, Cui H (January 2008). "Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA". Nature. 451 (7175): 202–6. Bibcode:2008Natur.451..202Y. doi:10.1038/nature06468. PMC 2743558. PMID 18185590.

[pmid16189514-10] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[pmid16169070-11] Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, et al. (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.

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Function

Interactions

References

Further reading

External links