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Protein-coding gene in humans
Cell division cycle protein 27 homolog is a protein that in humans is encoded by the CDC27 gene .[ 5] [ 6]
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Schizosaccharomyces pombe anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin -mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction . This protein was shown to interact with mitotic checkpoint proteins including Mad2 , p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis .[ 6]
CDC27 has been shown to interact with:
ANAPC10 ,[ 7] [ 8] ANAPC11 ,[ 7] [ 8] ANAPC1 ,[ 7] [ 9] ANAPC4 ,[ 7] [ 8] ANAPC5 ,[ 7] [ 8] [ 10] ANAPC7 ,[ 7] [ 8] CDC16 ,[ 7] [ 8] [ 11] [ 12] CDC20 ,[ 7] [ 11] [ 13] [ 14] [ 15] [ 16] [ 17] CDC23 ,[ 7] [ 8] CDH1 ,[ 7] FZR1 ,[ 13] [ 18] MAD2L1 [ 11] [ 16] PIN1 .[ 19] [ 20]
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