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Protein-coding gene in the species Homo sapiens
Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ANAPC7 gene .[ 5]
This gene encodes a tetratricopeptide repeat containing component of the anaphase-promoting complex /cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome -mediated degradation through ubiquitination . The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators .[ 5]
ANAPC7 has been shown to interact with ANAPC1 ,[ 6] [ 7] ANAPC4 ,[ 6] CDC27 [ 6] [ 8] CDC20 .[ 6] [ 9]
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