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Cyclin D3

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CCND3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCCND3, cyclin D3
External IDsOMIM: 123834; MGI: 88315; HomoloGene: 20419; GeneCards: CCND3; OMA:CCND3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

896

12445

Ensembl

ENSG00000112576

ENSMUSG00000034165

UniProt

P30281

P30282

RefSeq (mRNA)

NM_001081635
NM_001081636
NM_007632

RefSeq (protein)

NP_001075104
NP_001075105
NP_031658

Location (UCSC)Chr 6: 41.93 – 42.05 MbChr 17: 47.82 – 47.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

G1/S-specific cyclin-D3 is a protein that in humans is encoded by the CCND3 gene.[5]

Function

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The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation.[6]

Clinical significance

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Mutations in CCND3 are implicated in cases of breast cancer.[7]

Interactions

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Cyclin D3 has been shown to interact with:

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112576 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034165 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Inaba T, Matsushime H, Valentine M, Roussel MF, Sherr CJ, Look AT (July 1992). "Genomic organization, chromosomal localization, and independent expression of human cyclin D genes". Genomics. 13 (3): 565–574. doi:10.1016/0888-7543(92)90126-D. PMID 1386335.
  6. ^ "Entrez Gene: CCND3 cyclin D3".
  7. ^ Koboldt DC, Fulton RS, McLellan MD, Schmidt H, Kalicki-Veizer J, McMichael JF, et al. (Cancer Genome Atlas Network) (October 2012). "Comprehensive molecular portraits of human breast tumours". Nature. 490 (7418): 61–70. Bibcode:2012Natur.490...61T. doi:10.1038/nature11412. PMC 3465532. PMID 23000897.
  8. ^ a b Arsenijevic T, Degraef C, Dumont JE, Roger PP, Pirson I (March 2004). "A novel partner for D-type cyclins: protein kinase A-anchoring protein AKAP95". The Biochemical Journal. 378 (Pt 2): 673–679. doi:10.1042/BJ20031765. PMC 1223988. PMID 14641107.
  9. ^ Zhang S, Cai M, Zhang S, Xu S, Chen S, Chen X, et al. (September 2002). "Interaction of p58(PITSLRE), a G2/M-specific protein kinase, with cyclin D3". The Journal of Biological Chemistry. 277 (38): 35314–35322. doi:10.1074/jbc.M202179200. PMID 12082095.
  10. ^ a b Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  11. ^ a b c Lin J, Jinno S, Okayama H (April 2001). "Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence". Oncogene. 20 (16): 2000–2009. doi:10.1038/sj.onc.1204375. PMID 11360184.
  12. ^ a b Zhang Q, Wang X, Wolgemuth DJ (June 1999). "Developmentally regulated expression of cyclin D3 and its potential in vivo interacting proteins during murine gametogenesis". Endocrinology. 140 (6): 2790–2800. doi:10.1210/endo.140.6.6756. PMID 10342870.
  13. ^ a b Despouy G, Bastie JN, Deshaies S, Balitrand N, Mazharian A, Rochette-Egly C, et al. (February 2003). "Cyclin D3 is a cofactor of retinoic acid receptors, modulating their activity in the presence of cellular retinoic acid-binding protein II". The Journal of Biological Chemistry. 278 (8): 6355–6362. doi:10.1074/jbc.M210697200. PMID 12482873.
  14. ^ Meyerson M, Harlow E (March 1994). "Identification of G1 kinase activity for cdk6, a novel cyclin D partner". Molecular and Cellular Biology. 14 (3): 2077–2086. doi:10.1128/MCB.14.3.2077. PMC 358568. PMID 8114739.
  15. ^ Shen X, Yang Y, Liu W, Sun M, Jiang J, Zong H, et al. (August 2004). "Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3". FEBS Letters. 573 (1–3): 139–146. Bibcode:2004FEBSL.573..139S. doi:10.1016/j.febslet.2004.07.071. PMID 15327989. S2CID 16005938.

Further reading

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