Amylosucrase
| amylosucrase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.1.4 | ||||||||
| CAS no. | 9032-11-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, an amylosucrase (EC 2.4.1.4) is an enzyme that catalyzes the chemical reaction
- sucrose + (1,4-alpha-D-glucosyl)n D-fructose + (1,4-alpha-D-glucosyl)n+1
Thus, the two substrates of this enzyme are sucrose and (1,4-alpha-D-glucosyl)n, whereas its two products are D-fructose and (1,4-alpha-D-glucosyl)n+1.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is sucrose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase. Other names in common use include sucrose-glucan glucosyltransferase, and sucrose-1,4-alpha-glucan glucosyltransferase. This enzyme participates in starch and sucrose metabolism.
Structural studies
[edit]As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes 1G5A, 1JG9, 1JGI, 1MVY, 1MW0, 1MW1, 1MW2, 1MW3, 1S46, and 1ZS2.
References
[edit]- AVIGAD G, FEINGOLD DS, HESTRIN S (1957). "Enzymatic synthesis and reactions of a sucrose isomer alpha-D-galactopyranosyl-beta-D-fructofuranoside". J. Biol. Chem. 224 (1): 295–307. doi:10.1016/S0021-9258(18)65029-X. PMID 13398406.
- Hehre EJ (1951). "Enzymic Synthesis of Polysaccharides: A Biological type of Polymerization". Advances in Enzymology and Related Areas of Molecular Biology. Advances in Enzymology - and Related Areas of Molecular Biology. Vol. 11. pp. 297–337. doi:10.1002/9780470122563.ch6. ISBN 978-0-470-12256-3. PMID 24540594.
{{cite book}}:|journal=ignored (help) - Hehre EJ, Hamilton DM, Carlson AS (1949). "Synthesis of a polsaccharide of the starch glycogen class from sucrose by a cell-free, bacterial enzyme system (amylosucrase)". J. Biol. Chem. 177: 267–279. doi:10.1016/S0021-9258(18)57082-4.
