Allene oxide cyclase
| allene-oxide cyclase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 5.3.99.6 | ||||||||
| CAS no. | 118390-59-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, an allene-oxide cyclase (EC 5.3.99.6) is an enzyme that belongs to the family of isomerases, specifically a class of other intramolecular oxidoreductases. The systematic name of this enzyme class is (9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate isomerase (cyclizing).
The allene oxide of linolenic acid (i.e., (9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate) is converted by allene oxide cyclase to jasmonic acid ((15Z)-12-oxophyto-10,15-dienoate).[1]
Structural studies
[edit]As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1Z8K, 1ZVC, 2BRJ, 2DIO, 2GIN, and 2Q4I.
References
[edit]- ^ Schaller A, Stintzi A (September 2009). "Enzymes in jasmonate biosynthesis - structure, function, regulation". Phytochemistry. 70 (13–14): 1532–8. Bibcode:2009PChem..70.1532S. doi:10.1016/j.phytochem.2009.07.032. PMID 19703696.
- ^ Dewick, Paul (2009). Medicinal Natural Products: A Biosynthetic Approach. United Kingdom: John Wiley & Sons, Ltd. pp. 42–53. ISBN 978-0-470-74168-9.
- Hamberg M (October 1988). "Biosynthesis of 12-oxo-10,15(Z)-phytodienoic acid: identification of an allene oxide cyclase". Biochemical and Biophysical Research Communications. 156 (1): 543–50. doi:10.1016/S0006-291X(88)80876-3. PMID 3178850.
