Vinylacetyl-CoA Delta-isomerase
| Vinylacetyl-CoA Δ-isomerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 5.3.3.3 | ||||||||
| CAS no. | 9023-73-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a vinylacetyl-CoA Delta-isomerase (EC 5.3.3.3) is an enzyme that catalyzes the chemical reaction
- vinylacetyl-CoA crotonyl-CoA
Hence, this enzyme has one substrate, vinylacetyl-CoA, and one product, crotonyl-CoA.
This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is vinylacetyl-CoA Delta3-Delta2-isomerase. Other names in common use include vinylacetyl coenzyme A Delta-isomerase, vinylacetyl coenzyme A isomerase, and Delta3-cis-Delta2-trans-enoyl-CoA isomerase. This enzyme participates in butanoate metabolism.
Structural studies
[edit]As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1U8V.
References
[edit]- Lynen F, Knappe J, Lorch E, Jutting G, Ringelmann E (1959). "Die biochemische Funktion des Biotins". Angew. Chem. 71 (15–16): 481–486. doi:10.1002/ange.19590711503.
- Rilling HC; Coon MJ (1960). "The enzymatic isomerization of beta-methylvinylacetyl coenzyme A and the specificity of a bacterial beta-methylcrotonyl coenzyme A carboxylase". J. Biol. Chem. 235 (11): 3087–3092. doi:10.1016/S0021-9258(20)81314-3.
