Acetyl-CoA hydrolase
Appearance
acetyl-CoA hydrolase | |||||||||
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Identifiers | |||||||||
EC no. | 3.1.2.1 | ||||||||
CAS no. | 9027-54-7 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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The enzyme acetyl-CoA hydrolase (EC 3.1.2.1) catalyzes the reaction
acetyl-CoA + H2O CoA + acetate
This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name is CoA thiol esterase. This enzyme participates in pyruvate metabolism.
Structural studies
[edit]As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2H4U.
See also
[edit]- Acetyl-CoA synthetase and ACSS2, enzymes that perform the reverse reaction using ATP
References
[edit]- Gergely J, Hele P, Ramakrishnan CV (1952). "Succinyl and acetyl coenzyme A deacylases". J. Biol. Chem. 198 (1): 323–334. doi:10.1016/S0021-9258(18)55586-1. PMID 12999747.[permanent dead link]