Inositol monophosphatase 2

IMPA2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CZH, 2CZI, 2CZK, 2DDK, 2FVZ
Identifiers
Aliases	IMPA2, inositol monophosphatase 2
External IDs	OMIM: 605922; MGI: 2149728; HomoloGene: 22799; GeneCards: IMPA2; OMA:IMPA2 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	12,030,877 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; skin of abdomen; ; gastrocnemius muscle; ; skin of leg; ; muscle of thigh; ; human kidney; ; vulva; ; skin of thigh; ; Skeletal muscle tissue of rectus abdominis; ; mucosa of transverse colon;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	inositol monophosphate 1-phosphatase activity; inositol monophosphate phosphatase activity; hydrolase activity; protein binding; protein homodimerization activity; metal ion binding; inositol monophosphate 3-phosphatase activity; inositol monophosphate 4-phosphatase activity;
Cellular component	cytoplasm; cytosol;
Biological process	phosphate-containing compound metabolic process; phosphatidylinositol phosphate biosynthetic process; inositol phosphate metabolic process; inositol metabolic process; inositol biosynthetic process; signal transduction; inositol phosphate dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	3613
	114663
	ENSG00000141401
	n/a
	O14732
	Q91UZ5
	NM_014214
	NM_053261
	NP_055029
	NP_444491
	Wikidata
View/Edit Human	View/Edit Mouse

Inositol monophosphatase 2 is a 32 kDa enzyme that in humans is encoded by the IMPA2 gene.^[4]^[5] IMPA2 dephosphorylates myo-inositol monophosphate to myo-inositol.

The function of IMPA2 appears to be similar to IMPA1 within tissues; however, the genes are expressed differently in various tissues with IMPA2 expressed at the highest level in certain tissues of the brain and the lumen of the kidney. IMPA2 exists as a homodimer within cells and cannot form heterodimers with IMPA1.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141401 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yoshikawa T, Turner G, Esterling LE, Sanders AR, Detera-Wadleigh SD (Nov 1997). "A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder". Mol Psychiatry. 2 (5): 393–97. doi:10.1038/sj.mp.4000325. PMID 9322233. S2CID 24336959.
^ "Entrez Gene: IMPA2 inositol(myo)-1(or 4)-monophosphatase 2".
^ Ohnishi T, Ohba H, Seo KC, Im J, Sato Y, Iwayama Y, Furuichi T, Chung SK, Yoshikawa T (January 2007). "Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1". J. Biol. Chem. 282 (1): 637–46. doi:10.1074/jbc.M604474200. PMID 17068342.

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Yoshikawa T, Padigaru M, Karkera JD, Sharma M, Berrettini WH, Esterling LE, Detera-Wadleigh SD (2000). "Genomic structure and novel variants of myo-inositol monophosphatase 2 (IMPA2)". Mol. Psychiatry. 5 (2): 165–71. doi:10.1038/sj.mp.4000688. PMID 10822344. S2CID 25662931.
Sjøholt G, Gulbrandsen AK, Løvlie R, Berle JØ, Molven A, Steen VM (2000). "A human myo-inositol monophosphatase gene (IMPA2) localized in a putative susceptibility region for bipolar disorder on chromosome 18p11.2: genomic structure and polymorphism screening in manic-depressive patients". Mol. Psychiatry. 5 (2): 172–80. doi:10.1038/sj.mp.4000681. PMID 10822345. S2CID 21428994.
Yoon IS, Li PP, Siu KP, Kennedy JL, Cooke RG, Parikh SV, Warsh JJ (2002). "Altered IMPA2 gene expression and calcium homeostasis in bipolar disorder". Mol. Psychiatry. 6 (6): 678–83. doi:10.1038/sj.mp.4000901. PMID 11673796. S2CID 26050322.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Azzouz TN, Schumperli D (2004). "Evolutionary conservation of the U7 small nuclear ribonucleoprotein in Drosophila melanogaster". RNA. 9 (12): 1532–41. doi:10.1261/rna.5143303. PMC 1370506. PMID 14624008.
Sjøholt G, Ebstein RP, Lie RT, Berle JØ, Mallet J, Deleuze JF, Levinson DF, Laurent C, Mujahed M (2005). "Examination of IMPA1 and IMPA2 genes in manic-depressive patients: association between IMPA2 promoter polymorphisms and bipolar disorder". Mol. Psychiatry. 9 (6): 621–9. doi:10.1038/sj.mp.4001460. PMID 14699425. S2CID 28747842.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Nakayama J, Yamamoto N, Hamano K, Iwasaki N, Ohta M, Nakahara S, Matsui A, Noguchi E, Arinami T (2005). "Linkage and association of febrile seizures to the IMPA2 gene on human chromosome 18". Neurology. 63 (10): 1803–7. doi:10.1212/01.wnl.0000144499.34164.e0. PMID 15557493. S2CID 20201724.
Ohnishi T, Ohba H, Seo KC, Im J, Sato Y, Iwayama Y, Furuichi T, Chung SK, Yoshikawa T (2007). "Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1". J. Biol. Chem. 282 (1): 637–46. doi:10.1074/jbc.M604474200. PMID 17068342.
Ohnishi T, Yamada K, Ohba H, Iwayama Y, Toyota T, Hattori E, Inada T, Kunugi H, Tatsumi M (2007). "A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription". Neuropsychopharmacology. 32 (8): 1727–37. doi:10.1038/sj.npp.1301307. PMID 17251911.
Arai R, Ito K, Ohnishi T, Ohba H, Akasaka R, Bessho Y, Hanawa-Suetsugu K, Yoshikawa T, Shirouzu M (2007). "Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures". Proteins. 67 (3): 732–42. doi:10.1002/prot.21299. PMID 17340635. S2CID 46602105.
Blair MA, Ma S, Abou-Khalil B, Hedera P (2007). "Genetic variants in the IMPA2 gene do not confer increased risk of febrile seizures in Caucasian patients". Eur. J. Neurol. 14 (4): 424–7. doi:10.1111/j.1468-1331.2007.01702.x. PMID 17388992. S2CID 36906656.

External links

Overview of all the structural information available in the PDB for UniProt: O14732 (Human Inositol monophosphatase 2) at the PDBe-KB.

This article on a gene on human chromosome 18 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141401 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9322233-4] Yoshikawa T, Turner G, Esterling LE, Sanders AR, Detera-Wadleigh SD (Nov 1997). "A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder". Mol Psychiatry. 2 (5): 393–97. doi:10.1038/sj.mp.4000325. PMID 9322233. S2CID 24336959.

[entrez-5] "Entrez Gene: IMPA2 inositol(myo)-1(or 4)-monophosphatase 2".

[pmid17068342-6] Ohnishi T, Ohba H, Seo KC, Im J, Sato Y, Iwayama Y, Furuichi T, Chung SK, Yoshikawa T (January 2007). "Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1". J. Biol. Chem. 282 (1): 637–46. doi:10.1074/jbc.M604474200. PMID 17068342.

[1]

[2]

[3]

[4]

[5]

[6]

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

References

Further reading

External links