ARMCX6

ARMCX6
Identifiers
Aliases	ARMCX6, GASP10, armadillo repeat containing, X-linked 6, armadillo repeat containing X-linked 6
External IDs	MGI: 2147993; HomoloGene: 10373; GeneCards: ARMCX6; OMA:ARMCX6 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	101,618,001 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	133,652,166 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; body of pancreas; ; left adrenal cortex; ; smooth muscle tissue; ; islet of Langerhans; ; stromal cell of endometrium; ; spleen; ; monocyte; ; right coronary artery; ; lymph node;
	Top expressed in
	ovary; ; lens; ; neural tube; ; mesencephalon; ; epiblast; ; genital tubercle; ; hypothalamus; ; rhombencephalon; ; neural layer of retina; ; embryo;
	More reference expression data
	n/a
Orthologs
	54470
	278097
	ENSG00000198960
	ENSMUSG00000050394
	Q7L4S7
	Q8K3A6
	NM_001009584; NM_001184768; NM_019007
	NM_001007578
	NP_001009584; NP_001171697; NP_061880
	NP_001007579
	Wikidata
View/Edit Human	View/Edit Mouse

Armadillo repeat containing X-linked 6 is a protein that in humans is encoded by the ARMCX6 gene located on the X-chromosome.^[5]

It is one of six armadillo repeats containing X-linked proteins (ARMCX1, ARMCX2, ARMCX3, ARMCX4, ARMCX5, and ARMCX6 (this protein)).

The function of this protein is unknown at this time.

Protein sequence

     1 MGRAREVGWM AAGLMIGAGA CYCVYKLTIG RDDSEKLEEE 
    41 GEEEWDDDQE LDEEEPDIWF DFETMARPWT EDGDWTEPGA 
    81 PGGTEDRPSG GGKANRAHPI KQRPFPYEHK NTWSAQNCKN 
   121 GSCVLDLSKC LFIQGKLLFA EPKDAGFPFS QDINSHLASL 
   161 SMARNTSPTP DPTVREALCA PDNLNASIES QGQIKMYINE 
   201 VCRETVSRCC NSFLQQAGLN LLISMTVINN MLAKSASDLK 
   241 FPLISEGSGC AKVQVLKPLM GLSEKPVLAG ELVGAQMLFS 
   301 FMSLFIRNGN REILLETPAP

Homology

ARMCX6 is conserved in many eukaryotic organisms.

Orthologs

taxonomic name	common name	NCBI entry	Percentage of sequence similarity	Length (AAs)	comments
Homo sapiens	Human	[1]	100%	300	armadillo repeat containing X-linked 6
Macaca mulatta	Rhesus monkey	[2]	97.0%	300	PREDICTED: similar to amrmadillo repeat containing, X-linked 6 (H. sapiens)-like isoform 1
Equus caballus	Horse	[3]	90.0%	300	PREDICTED: similar to armadillo repeat containing, X-linked 6
Danio rerio	zebrafish	[4]	84.0%	301	Similar to RIKEN cDNA 0610039K22
Mus musculus	House Mouse	[5]	97.7%	393	armadillo repeat containing, X-linked 6 (H. sapiens)-like
Bos taurus	cow	[6]	83.0%	301	armadillo repeat containing, X-linked 6
Mus musculus	Mouse	[7]	82.0%	301	armadillo repeat containing, X-linked 6
Takifugu rubripes	Tetradontoidea	[8]	66.0%	818	aryl hydrocarbon receptor 2C
Caenorhabditis elegans	C. elegans	[9]	50.0%	332	Serpentine Receptor, class H family member (srh-216)
Saccharomyces cerevisiae	Yeast	[10]	70.0%	910	Hul5p
Gallus gallus	Chicken	[11]	52.0%	317	PREDICTED: hypothetical protein

Secondary Structure

The secondary structure of ARMCX6 is predicted to be similar to cyanase. A comparison of the two sequences is shown below.^[6]^[7]

                          10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
ARMCX6      231 MLAKSASDLKFPLISEGSGCAKVQVLKPLMGLSEKPVLAGELVGAQM 277
1DW9_A       19 LLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKL 65
                 + +   ++ +  +  + + +   +   + +    +  +  ++++

Cyanase segment having identity with ARMCX6.

Expression

Microarray data show that ARMCX6 is highly expressed during earliest stages of spermatogenesis in mice.^[8]^[9]^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198960 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050394 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: armadillo repeat containing".
^ SDSC Biology Workbench 2.0
^ "CBlast service is retiring".
^ EST Profile Viewer- Human
^ EST Profile Viewer- Mouse
^ Su AI, Wiltshire T, Batalov S, Lapp H, et al. (April 2004). "A gene atlas of the mouse and human protein-encoding transcriptomes". Proceedings of the National Academy of Sciences of the United States of America. 101 (16): 6062–7. Bibcode:2004PNAS..101.6062S. doi:10.1073/pnas.0400782101. PMC 395923. PMID 15075390.

External links

Human ARMCX6 genome location and ARMCX6 gene details page in the UCSC Genome Browser.

Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198960 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050394 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: armadillo repeat containing".

[biobench-6] SDSC Biology Workbench 2.0

[C_BLAST-7] "CBlast service is retiring".

[esthum-8] EST Profile Viewer- Human

[estmus-9] EST Profile Viewer- Mouse

[gds596-10] Su AI, Wiltshire T, Batalov S, Lapp H, et al. (April 2004). "A gene atlas of the mouse and human protein-encoding transcriptomes". Proceedings of the National Academy of Sciences of the United States of America. 101 (16): 6062–7. Bibcode:2004PNAS..101.6062S. doi:10.1073/pnas.0400782101. PMC 395923. PMID 15075390.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]