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4-nitrophenylphosphatase

From Wikipedia, the free encyclopedia
4-nitrophenylphosphatase
Identifiers
EC no.3.1.3.41
CAS no.9073-68-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

The enzyme 4-nitrophenylphosphatase (EC 3.1.3.41) catalyzes the reaction

4-nitrophenyl phosphate + H2O 4-nitrophenol + phosphate

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is 4-nitrophenylphosphate phosphohydrolase. Other names in common use include nitrophenyl phosphatase, p-nitrophenylphosphatase, para-nitrophenyl phosphatase, K-pNPPase, NPPase, PNPPase, Ecto-p-nitrophenyl phosphatase, and p-nitrophenylphosphate phosphohydrolase. This enzyme participates in γ-hexachlorocyclohexane degradation.

Structural studies

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As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB: 1VJR​.

References

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  • Attias J, Bonnet JL (1972). "A specific alkaline p-nitrophenylphosphatase activity from baker's yeast". Biochim. Biophys. Acta. 268 (2): 422–30. doi:10.1016/0005-2744(72)90338-5. PMID 4554643.
  • Attias J, Durand H (1973). "Further characterization of a specific p-nitrophenylphosphatase from baker's yeast". Biochim. Biophys. Acta. 321 (2): 561–8. doi:10.1016/0005-2744(73)90199-x. PMID 4357666.