The knockout stage of the 2010 Africa Cup of Nations was the second and final stage of the competition, following the group stage. It began on 24 January with the quarter-finals and ended on 31 January 2010 with the final held at the Estádio 11 de Novembro in Luanda. A total of 8 teams (the top two teams from each group) advanced to the knockout stage to compete in a single-elimination style tournament.
In the knockout stage, except for the third place play-off, if a match was level at the end of 90 minutes of normal playing time, extra time was played (two periods of 15 minutes each). If still tied after extra time, the match was decided by a penalty shoot-out to determine the winner. In the third place play-off, if the scores remained level after 90 minutes the match would go directly to a penalty shoot-out, without any extra time being played.