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2,8-Dihydroxyhexahydrochrysene

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2,8-Dihydroxyhexahydrochrysene
Clinical data
ATC code
  • None
Identifiers
PubChem CID
ChemSpider
Chemical and physical data
FormulaC18H18O2
Molar mass266.340 g·mol−1
3D model (JSmol)
  • OC1C=CC2=C(C=1)CCC3C2CCC4C3=CC=C(O)C=4
  • InChI=1S/C18H18O2/c19-13-3-7-15-11(9-13)1-5-17-16-8-4-14(20)10-12(16)2-6-18(15)17/h3-4,7-10,17-20H,1-2,5-6H2
  • Key:WKSBLYZBEPGLTB-UHFFFAOYSA-N

2,8-Dihydroxyhexahydrochrysene (2,8-DHHHC) is a synthetic, nonsteroidal weak estrogen with approximately 1/2,000th the estrogenic potency of the structurally-related estrogen diethylstilbestrol.[1][2][3] It is said to be intermediate in structure between estradiol and hexestrol, but conversely to both of them, it is drastically less potent in comparison.[3]

See also

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References

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  1. ^ Maximov PY, McDaniel RE, Jordan VC (23 July 2013). Tamoxifen: Pioneering Medicine in Breast Cancer. Springer Science & Business Media. pp. 4–. ISBN 978-3-0348-0664-0.
  2. ^ Jordan VC (1986). Estrogen/antiestrogen Action and Breast Cancer Therapy. Univ of Wisconsin Press. pp. 22–. ISBN 978-0-299-10480-1.
  3. ^ a b Wilds AL, Sutton RE (1951). "Cyclic Analogs of Hexestrol in the Chrysene Series". The Journal of Organic Chemistry. 16 (9): 1371–1379. doi:10.1021/jo50003a006. ISSN 0022-3263.


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