Zinc finger protein 426

ZNF426
Identifiers
Aliases	ZNF426, K-RBP, zinc finger protein 426
External IDs	MGI: 1920248; HomoloGene: 23435; GeneCards: ZNF426; OMA:ZNF426 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	9,538,645 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	20,404,042 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; oral cavity; ; amniotic fluid; ; parotid gland; ; epithelium of esophagus; ; retinal pigment epithelium; ; vena cava; ; Achilles tendon; ; sperm;
	Top expressed in
	tail of embryo; ; genital tubercle; ; zygote; ; spermatid; ; ventricular zone; ; spermatocyte; ; granulocyte; ; lens; ; Rostral migratory stream; ; neural layer of retina;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; protein binding; metal ion binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	intracellular anatomical structure; nucleus;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	79088
	235028
	ENSG00000130818
	ENSMUSG00000059475
	Q9BUY5
	Q8R1D1
	NM_001300883; NM_024106; NM_001318055; NM_001318056
	NM_001110309; NM_146221; NM_001310742
	NP_001287812; NP_001304984; NP_001304985; NP_077011
	NP_001103779; NP_001297671; NP_666333
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein 426 is a protein that in humans is encoded by the ZNF426 gene. ^[5]

Function

Kaposi's sarcoma-associated herpesvirus (KSHV) can be reactivated from latency by the viral protein RTA. The protein encoded by this gene is a zinc finger transcriptional repressor that interacts with RTA to modulate RTA-mediated reactivation of KSHV. While the encoded protein can repress KSHV reactivation, RTA can induce degradation of this protein through the ubiquitin-proteasome pathway to overcome the repression. Several transcript variants encoding different isoforms have been found for this gene.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130818 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059475 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Zinc finger protein 426". Retrieved 2016-01-28.

Function

References

Further reading