ZBTB1

ZBTB1
Identifiers
Aliases	ZBTB1, ZNF909, zinc finger and BTB domain containing 1
External IDs	OMIM: 616578; MGI: 2442326; HomoloGene: 8974; GeneCards: ZBTB1; OMA:ZBTB1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	64,533,690 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	76,443,724 bp
RNA expression pattern
	Top expressed in
	sperm; ; Achilles tendon; ; lymph node; ; right uterine tube; ; mononuclear cell; ; monocyte; ; skin of hip; ; cartilage tissue; ; germinal epithelium; ; stromal cell of endometrium;
	Top expressed in
	cumulus cell; ; lacrimal gland; ; hair follicle; ; trigeminal ganglion; ; blood; ; sciatic nerve; ; lymph node; ; conjunctival fornix; ; female urethra; ; ascending aorta;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; protein homodimerization activity; metal ion binding; K63-linked polyubiquitin modification-dependent protein binding; protein binding; protein heterodimerization activity; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nuclear body; nucleoplasm; nucleus; nuclear membrane;
Biological process	positive regulation of T cell differentiation; chromatin remodeling; cell differentiation; positive regulation of pro-T cell differentiation; regulation of transcription, DNA-templated; positive regulation of natural killer cell differentiation; T cell differentiation in thymus; thymus development; immune system process; cellular response to UV; mRNA transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of T cell mediated immunity; translesion synthesis; B cell differentiation; innate immune response; protein homooligomerization; DNA repair; cellular response to DNA damage stimulus;
	Sources:Amigo / QuickGO
Orthologs
	22890
	268564
	ENSG00000126804
	ENSMUSG00000033454
	Q9Y2K1
	Q91VL9
	NM_001123329; NM_014950
	NM_178744; NM_001364323
	NP_001116801; NP_055765
	NP_848859; NP_001351252
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger and BTB domain containing 1 is a protein in humans that is encoded by the ZBTB1 gene.^[5]

ZBTB1 is essential for the development of lymphocytes in mice: T cells are absent from ZBTB1 mutant mice, and numbers of B cells and natural killer cells are reduced.^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000126804 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033454 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Zinc finger and BTB domain containing 1".
^ Siggs OM, Li X, Xia Y, Beutler B (January 2012). "ZBTB1 is a determinant of lymphoid development". The Journal of Experimental Medicine. 209 (1): 19–27. doi:10.1084/jem.20112084. PMC 3260866. PMID 22201126.
^ Punwani D, Simon K, Choi Y, Dutra A, Gonzalez-Espinosa D, Pak E, Naradikian M, Song CH, Zhang J, Bodine DM, Puck JM (August 2012). "Transcription factor zinc finger and BTB domain 1 is essential for lymphocyte development". Journal of Immunology. 189 (3): 1253–64. doi:10.4049/jimmunol.1200623. PMC 3401355. PMID 22753936.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000126804 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033454 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Zinc finger and BTB domain containing 1".

[pmid22201126-6] Siggs OM, Li X, Xia Y, Beutler B (January 2012). "ZBTB1 is a determinant of lymphoid development". The Journal of Experimental Medicine. 209 (1): 19–27. doi:10.1084/jem.20112084. PMC 3260866. PMID 22201126.

[pmid22753936-7] Punwani D, Simon K, Choi Y, Dutra A, Gonzalez-Espinosa D, Pak E, Naradikian M, Song CH, Zhang J, Bodine DM, Puck JM (August 2012). "Transcription factor zinc finger and BTB domain 1 is essential for lymphocyte development". Journal of Immunology. 189 (3): 1253–64. doi:10.4049/jimmunol.1200623. PMC 3401355. PMID 22753936.

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