YAF2

YAF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D9G
Identifiers
Aliases	YAF2, YY1 associated factor 2
External IDs	OMIM: 607534; MGI: 1914307; HomoloGene: 136401; GeneCards: YAF2; OMA:YAF2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	42,238,349 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	93,234,816 bp
RNA expression pattern
	Top expressed in
	right auricle; ; Achilles tendon; ; gastrocnemius muscle; ; epithelium of colon; ; left ventricle; ; muscle of thigh; ; ventricular zone; ; sural nerve; ; ganglionic eminence; ; gonad;
	Top expressed in
	Region I of hippocampus proper; ; barrel cortex; ; epithelium of lens; ; retinal pigment epithelium; ; substantia nigra; ; Epithelium of choroid plexus; ; iris; ; prefrontal cortex; ; blood; ; external carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; transcription coactivator activity; transcription corepressor activity;
Cellular component	nucleus; cytosol; nucleoplasm;
Biological process	positive regulation of transcription, DNA-templated; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of G0 to G1 transition;
	Sources:Amigo / QuickGO
Orthologs
	10138
	67057
	ENSG00000015153
	ENSMUSG00000022634
	Q8IY57
	Q99LW6
NM_001012424; NM_001190977; NM_001190979; NM_001190980; NM_005748;
	NM_001320080
	NM_024189
	NP_001177906; NP_001177908; NP_001177909; NP_001307009; NP_005739
	NP_077151
	Wikidata
View/Edit Human	View/Edit Mouse

YY1-associated factor 2 is a protein that in humans is encoded by the YAF2 gene.^[5]^[6]

The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000015153 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022634 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kalenik JL, Chen D, Bradley ME, Chen SJ, Lee TC (Mar 1997). "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1". Nucleic Acids Res. 25 (4): 843–9. doi:10.1093/nar/25.4.843. PMC 146511. PMID 9016636.
^ ^a ^b "Entrez Gene: YAF2 YY1 associated factor 2".

External links

YAF2 human gene location in the UCSC Genome Browser.
YAF2 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000015153 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022634 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9016636-5] Kalenik JL, Chen D, Bradley ME, Chen SJ, Lee TC (Mar 1997). "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1". Nucleic Acids Res. 25 (4): 843–9. doi:10.1093/nar/25.4.843. PMC 146511. PMID 9016636.

[entrez-6] "Entrez Gene: YAF2 YY1 associated factor 2".

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References

Further reading

External links