Wikipedia:USEP/Courses/JHU MolBio Ogg SP14/Group 81B

Initial article assessments from Gkaltam

45s precursor

This article is currently not written on Wikipedia. Therefore, there is no talk page nor is there any information pertaining to this topic. In order to write a good article about this topic, there must be a sufficient amount of information to be gathered and written. The article should be referenced correctly and perhaps should have some images.

Compiled Bibliography

1.Layat, E; Sáez-Vásquez, J; Tourmente, S (2012 Feb). "Regulation of Pol I-transcribed 45S rDNA and Pol III-transcribed 5S rDNA in Arabidopsis.". Plant & cell physiology 53 (2): 267–76. PMID 22173098

2.Hadjiolov, AA; Milchev, GI (1974 Aug). "Synthesis and maturation of ribosomal ribonucleic acids in isolated HeLa cell nuclei. A tracer study on the topology of the 45S precursor of ribosomal ribonucleic acids.". The Biochemical journal 142 (2): 263–72. PMID 4474879.

3. Torelli, UL; Ferrari, S; Torelli, GM; Cadossi, R; Ferrari, S; Montagnani, G; Narni, F (1977 Dec). "In vitrocleavage of 45S pre-ribosomal RNA and of giant heterogeneous RNA extracted from human leukemic cells.". Molecular biology reports 3 (6): 403–11. PMID 593270.

4. Harrington, CA; Chikaraishi, DM (1983 May 25). "Identification and sequence of the initiation site for rat 45S ribosomal RNA synthesis.". Nucleic Acids Research 11 (10): 3317–32. PMID 6304628.

5. Stevens, RH; Amos, H (1971 Sep). "RNA metabolism in HeLa cells at reduced temperature. I. Modified processing of 45S RNA.". The Journal of cell biology 50 (3): 818–29. PMID 5098867

AP-1 Binding Site

This article is currently characterized as a stub on Wikipedia. It only has one piece of information on it with one reference. The reference is cited incorrectly in text. In order for this article to become a good article, it will need a significant amount of information added with correct referencing. In addition, it should be written well, and with diagrams is possible.

Compiled Bibliography

1. Suzuki, S; Nishio, SI; Ishii, H; Sekido, T; Takeshige, K; Ohkubo, Y; Hiwatashi, D; Takeda, T; Komatsu, M (2013 Jul). "Possible roles of the AP-1 site in the cytosolic T3 binding protein promoter and insights into its physiological significance.". Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 45 (7): 501–6. PMID 23508717.

2. Colin, L; Vandenhoudt, N; de Walque, S; Van Driessche, B; Bergamaschi, A; Martinelli, V; Cherrier, T; Vanhulle, C; Guiguen, A; David, A; Burny, A; Herbein, G; Pancino, G; Rohr, O; Van Lint, C (2011 Apr 19). "The AP-1 binding sites located in the pol gene intragenic regulatory region of HIV-1 are important for viral replication.". PLoS ONE 6 (4): e19084. PMID 21526160.

3.Hu, F; Meng, Y; Gou, L; Zhang, X (2013 Nov). "Analysis of promoters and CREB/AP-1 binding sites of the human TMEM174 gene.". Experimental and therapeutic medicine 6 (5): 1290–1294. PMID 24223660.

4. González-Ramos, M; Mora, I; de Frutos, S; Garesse, R; Rodríguez-Puyol, M; Olmos, G; Rodríguez-Puyol, D (2012 Jun). "Intracellular redox equilibrium is essential for the constitutive expression of AP-1 dependent genes in resting cells: studies on TGF-β1 regulation.". The international journal of biochemistry & cell biology 44 (6): 963–71. PMID 22429882

Initial article assessments from Mmehta10

Heat shock protein 70 (Hsp70) internal ribosome entry site (IRES)

This topic is currently classified as a stub with a basic introduction to heat shock proteins with just one reference. It also has an external reference link with exactly the same information as present on Wikipedia. For this to become a good article for Wikipedia, more detailed meaningful information should be added. Along with the content, more references should be used in order to create a more complete and reliable.

Compiled Bibliography

1. Li, Z; Srivastava, P (February 2004). "Heat-shock proteins". Current protocols in immunology / edited by John E. Coligan ... [et al.] Appendix 1: Appendix 1T. doi:10.1002/0471142735.ima01ts58. ISBN 0471142735. PMID 18432918.

2. Sun, Y; MacRae, TH (June 2005). "The small heat shock proteins and their role in human disease". The FEBS Journal. 272 (11): 2613–27. doi:10.1111/j.1742-4658.2005.04708.x. PMID 15943797.

3. Takayama, S; Reed, JC; Homma, S (8 December 2003). "Heat-shock proteins as regulators of apoptosis". Oncogene. 22 (56): 9041–7. doi:10.1038/sj.onc.1207114. PMID 14663482.

4. Lodish, Harvey (2008). Molecular cell biology (6th ed.). New York [u.a.]: Freeman. p. 76. ISBN 978-0-7167-7601-7.

Spermatocyte

This article has also been deemed as a stub due to lack of detailed content. It does have some pictures showing the histology and process of maturation of the spermatocyte however there are no citations listed. In order for this to become a good article, some detailed, well-structured information needs to be added referencing reliable sources.

Compiled Bibliography

1. Alberts B, Johnson A, Lewis J, et al. Molecular Biology of the Cell. 4th edition. New York: Garland Science; 2002. Sperm. Available from: http://www.ncbi.nlm.nih.gov/books/NBK26914/

2. Looijenga, LH; Hersmus, R; Gillis, AJ; Pfundt, R; Stoop, HJ; van Gurp, RJ; Veltman, J; Beverloo, HB; van Drunen, E; van Kessel, AG; Pera, RR; Schneider, DT; Summersgill, B; Shipley, J; McIntyre, A; van der Spek, P; Schoenmakers, E; Oosterhuis, JW (1 January 2006). "Genomic and expression profiling of human spermatocytic seminomas: primary spermatocyte as tumorigenic precursor and DMRT1 as candidate chromosome 9 gene". Cancer Research. 66 (1): 290–302. doi:10.1158/0008-5472.CAN-05-2936. PMID 16397242.

3. Dyer, N; Rebollo, E; Domínguez, P; Elkhatib, N; Chavrier, P; Daviet, L; González, C; González-Gaitán, M (December 2007). "Spermatocyte cytokinesis requires rapid membrane addition mediated by ARF6 on central spindle recycling endosomes". Development. 134 (24): 4437–47. doi:10.1242/dev.010983. PMID 18039970.

Initial article assessments from Reese Langer

Differentiation-inducing factor

The article is considered a stub. It lacks a bulk of information. There is only one reference listed but it is not cited anywhere in the small amount of text. For this to be a good article it needs the addition of a lot of meaningful, well written information. Also it needs sources that are correctly referenced.

Compiled Bibliography

1. Yasimin T, Takahashi-Yanaga F, Mori J, Miwa Y, Hirata M, Watanabe Y, Morimoto S, Sasaguri T. (2005 Dec) Differentialtion-Inducing factor-1 suppresses gene expression of cyclin D1 in tumor cells. Biochem Biophys Res Commun, 338(2);903-9 :16243295

2. Matsuzaki E, Takahashi-Yanaga F, Miwa Y, Hirata M, Watanake Y, Sato N, Morimotos, Hirofuji T, Maeda K, Sasagur T. (2006 Aug) J Bone Miner Res 8;1307-16 : 16869729

Nondisjunction

This article is currently classified as 'bigger than a stub'. This means it has some meaningful information however it needs to be elaborated upon. It has onely 1 reference listed. Its sources are still unknown because it lacks inline citation. To build upon this article it needs more detailed and precise information along with more precise citations.

Compiled Bibliography

1. Middlebrooks CD, Mukhopadhyay N, Tinker SW, Allen EG, Bean LJ, Begum F, Chowdhury R, Cheung V, Doheny K, Adams M, Feingold E,Sherman SL. (2013 Sep) Evidence for dysregulation of genome-wide recombination in oocytes with nondisjoined chromosomes 21. Epub 15; 23(2);408-17; 24014426

2. Valind A, Jun Y, Baldetorp B, Gisselsson D. (2013 Dec) Whole chromosome gain does not in itself confer cancer-like chromosomal instability. Epub;110(52); 2119-23 24324169

Article Selection Rationale

The article on AB5 toxin has been classified as 'bigger than a stub' so it has some meaningful pieces of information available currently however; we would like to expand upon this to benefit the learning community even more. As avid researchers, we don't feel the rating of 'low' importance by molecular and cellular biology wikiproject should lower our curiosity for this topic. By means of the talk page, we would like to initiate discussions about this protein. We also hope to elaborate various aspects of this toxin and have thought of adding an infobox with some key information. This infobox would contain information from reliable external sources for example the protein data bank accession numbers, the crystal structures of A and B subunits separately via NCBI structure database and much more. In addition, images or diagrams will be added in order to help readers visualize the protein.

Some Additional Topics to include in the Article

1. Current uses of this toxin in drugs

2. Details about A and B subunits

3. Examples of this toxin from various species

Progress Report for Unit 12

Gkaltam/ Grittney- Prose contributions, added B subunit image, Drew general diagram of A subunit and uploaded to article, more prose

Mmehta10/ Misha-

• Further elucidated the structure of AB5 toxin, specifically chains within the A subunit
• Uploaded image of A subunit to Wikimedia Commons and article
• Prose contributions

ReeseLanger/ Craiteyka - prose contributions

Progress Report for Unit 14

Gkaltam/Grittney- prose contributions, added B subunit image, Drew general diagram of A subunit and uploaded to article, Drew mechanisms diagram and uploaded to article, found images for families section

Used many suggestions from our peer reviewers such as Klortho, Kneal0627, Wpeissner, Ssumpf, and Previte01

Mmehta10/ Misha-

• Prose contributions, Article formatting
• Made several edits to the article based on OA and peer reviews.

ReeseLanger/Craiteyka - prose