Wikipedia:USEP/Courses/JHU MolBio Ogg FA13/Group 81E
Group 81E
[edit]This is a group page for the Johns Hopkins Molecular Biology course. This group will be working on the article TBD.
Use the talk page here to collaborate as a group, when learning to use and navigate Wikipedia, assessing articles, or for any other topic.
Use this page (not the talk page) for article assessments; rationale for selecting an article; etc (as specified in the milestone summary chart.
Please create a new section here for each of those assignments.
Initial Article Assessments from Rokasj1
[edit]Histone Octamer
[edit]This article is only a stub, has short and choppy 5 sentences. Layout is nonexistent. Furthermore, this article on histone octamers has no references; therefore no information on it has been verified. Also it is missing illustrations. Article has been rated “high importance” so it might be a good idea to expand it into a good article since in the talk pages there is no plans on doing so at the moment.
Ribonucleoprotein
[edit]This article is a stub. It is also a short 2 paragraph article with neither in line citations or references, therefore none of the information in it is verified. It has rudimentary structure info on ribonuceoprotein and a sentence on potential role as it pertains to human health. Also, the list of ribonucleoproteins is provided, which can be extended into different paragraphs. Article on ribonucleoproteins needs to be broadened and include some images.
Potential references:
Initial Article Assessments by Dmille96
[edit]Gene Knockdown
[edit]This article is a stub. There are three major subheadings to the article which cover small topics related to gene knockdown but overall it fails to provide the complete picture of the topic. The topic has a small number of articles pertaining to the subject. The article shares some of its information with the gene knockout article but provides little information to separate itself. The talk page has a bit of information cooking but it seems pretty light. Overall it appears we would have some help working with this topic. The importance rating on the article is high making it a nice target for improvement. My personal feelings on the matter: it will be difficult to make this article without running into problems with the gene knockout territory as the two are rather interrelated. Still its an interesting topic worth attention. Not sure we can get it to GA.
Viral Transformation
[edit]This article is also a stub with high importance. This article is very much in its beginnings. It has no sources for any of the information written. The only large body of text shares information with another wikipedia article. Overall this article would be a large undertaking. The article lacks the basic groundwork that the gene knockdown article has and overall lacks a depth of information. Bringing this article to GA would be quite the effort but it seems like we would be working largely on our own as the talk page is pretty dead. You can view this as a good or bad thing but that seems to be the scenario.
Article selection Rationale
[edit]Rokasj1 Selection Rationale
[edit]We chose an article Histone Octamers because it is very underdeveloped (categoriezed as stub article) and it was rated as a highly important article on Wikipedia. Our group finds the topic of Histone Octamer to be also relevant to our Molecular Biology class because it is a fundamental component of genome structure and chromatin. The reason for choosing article on Histone Octamers is also due to the fact that it seems to be narrow enough to be fully developed in the remainder of the semester. Our group suggests the following structure for this article:
Core histone, linker histone: histones most abundant protein in eukaryotic DNA, highly positive molecules
Histones form intermediate assemblies in solution
Histone tails: stabilization of the DNA wrapping. Numerous possible modifications at lysine arginine and serine residues can occur on histone tails. Potential implications on the nucleosome function as a result of these modifications.
Dmille96 rationale for selection
[edit]We ended up choosing the histone octamer article as our target article for several reasons. First, we liked the idea of starting from a very basic article. The histone octamer has only a couple of sentences so far and no references. Starting from a clean slate seemed like the best option since we would end up with a lot of control over how the article was shaped and the style with which it would be written. Second, we believe that this topic is extremely important and in need of a Wikipedia article. The article has been rated as such being given a “high importance” rating. Covering this topic would be a great help to anyone interested, especially those at the lower levels of education as indicated by the rating. Combine this with the fact that there is only the most basic information present makes it a desirable target. Third, we chose this article because it is a topic we feel we have a solid grasp on. We have already covered the basics of histone octamers in class and would be able to quickly build a structure for the creation of the article. Rokas in particular feels comfortable working with proteins so that also influenced our decision. Finally, we believe that the topic is well researched to a degree that building a near-complete article is a feasible goal. We feel that on top of our already basic knowledge, we will have a great depth of information available to us through peer-reviewed research. All in all these factors have guided us to the conclusion that the histone octamer article is the article for us.
Week 8 Update
[edit]- All major contributions were prose
- Wiki-linking was done for the introduction
- histone octamer research history paragraph added in, with citations all prose.
Week 10 Update
[edit]- Added new sections to frame our article
- Prose additions to two sections
- Fixed Wiki-linking issues from previous additions
- Added a picture, might require removal
- Removed unreferenced article tag as we now have several sources
Week 12 Update
[edit]- Prose additions in three sections
- Removed expand section/subsection markers
- Added new Wikilinking
- Edited previous section in response to requests
Week 14 update
[edit]- Prose additions and revisions to all sections
- Extensive expansion of wikilinking in subsections
- Picture added
- Citations fixed and expanded
- Formatting revisions based on suggestions
References
[edit]- ^ James D. Watson; et al. (2007). Molecular biology of the gene (6th ed.). San Francisco: Benjamin Cummings. ISBN 9780805395921.
- ^ Petta, V; Gkiozos, I; Strimpakos, A; Syrigos, K (14 September 2013). "Histones and lung cancer: are the histone deacetylases a promising therapeutic target?". Cancer Chemotherapy and Pharmacology. 72 (5): 935–52. doi:10.1007/s00280-013-2223-9. PMID 24036844. S2CID 24696721.
- ^ Lee, SR; Lykke-Andersen, J (October 2013). "Emerging roles for ribonucleoprotein modification and remodeling in controlling RNA fate". Trends in Cell Biology. 23 (10): 504–10. doi:10.1016/j.tcb.2013.05.001. PMC 3983964. PMID 23756094.
- ^ Skipper, Magdalena (1 July 2001). "TECHNOLOGY: It's a knock-down". Nature Reviews Genetics. 2 (7): 486. doi:10.1038/35080503. S2CID 38769908.
- ^ Mocellin, Simone; Provenzano, Maurizio (1 January 2004). "RNA interference: learning gene knock-down from cell physiology". Journal of Translational Medicine. 2 (1): 39. doi:10.1186/1479-5876-2-39. PMC 534783. PMID 15555080.
- ^ Ferrari, Roberto; Berk, Arnold J.; Kurdistani, Siavash K. (May 2009). "Viral manipulation of the host epigenome for oncogenic transformation". Nature Reviews Genetics. 10 (5): 290–294. doi:10.1038/nrg2539. PMC 2692573. PMID 19290008.
- ^ Bangham, Jenny (1 April 2006). "A step towards viral transformation". Nature Reviews Cancer. 6 (4): 254–255. doi:10.1038/nrc1871. S2CID 40037964.