Wikipedia:Peer review/Acute myeloid leukemia/archive1

Acute myeloid leukemia

Hello - I'm looking for comments on ways in which this page could be improved, made more useful, re-formatted, etc with the goal of getting it into good article/featured article shape. On another note, any appropriate images would be greatly appreciated. MastCell 21:10, 21 August 2006 (UTC)[reply]

Looks pretty good overall. A few ideas:

In the lead: "Much progress has been made" is a little weaselly, and the statement about fatality needs a citation (even if that is implicit in the category of "acute leukemia", general readers won't know that). Also, "bone marrow and elsewhere" is awkward.
The lead mentions research on causes of AML, but there's not much mention of current research in the article text itself. I believe in particular that AML and ALL are often used as test cases in genomics and microarray technologies designed to distinguish stereotypical cancer genotypes and predict prognoses.
What is meant by the description of the cells as "immature"?
In the History section: "when Velpeau described a 63-year-old florist..." - Velpeau is neither introduced nor wikilinked.
Causes section should be prose (it practically already is; such long explanations kind of defeat the purpose of a bulleted list).
It's not clear to me whether organic solvents have been implicated in causing AML specifically, or leukemia in general.
The lead mentions the incidence-age correlation but the text contains no data on incidence more generally. A section on these subjects (any correlation with gender or ethnic groups? different rates in different countries? etc.) would be useful.
It seems useful to give a brief explanation of why displacing normal bone marrow cells is bad. Just a brief expansion in the pathophysiology section to be more clear.
Consider moving symptoms (and possibly diagnosis) above the classification scheme. Most people who read the article are probably looking for clinical information, not differences in international classification methodologies.
Are there any typical or canonical genetic variations in the cancerous cells? The mention of chromosomal translocation tests suggests maybe, but I don't know.
Is the cure rate 20-30% overall, or with treatments not including bone marrow transplantation? The prognosis section implies the former and the end of the treatment section sounds like it could be the latter.

Opabinia regalis 01:19, 24 August 2006 (UTC)[reply]

The sentence in the introduction that states that the disease is curable, but not usually by current therapy seems self-contradictory.
The article states that the mutations in pregression from a pre-malignant cell to a malignant cell only seen in transcription factors. From a brief skim of Pubmed I suspect there is also involvement of signalling proteins or apoptotic regulators. Ref1 Ref2

TimVickers 22:45, 28 August 2006 (UTC)[reply]

Thanks for the suggestions; I've done my best to incorporate them, although some are beyond what I can address knowledgably and so would need help from other expert editors. Input is much appreciated. MastCell 04:21, 29 August 2006 (UTC)[reply]