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Coombs test

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Original
Reason
This is a very high quality image. Very informative and educational. Meets all the requirements needed to become a featured picture.
Proposed caption
Coombs test (also known as Coombs' test, antiglobulin test or AGT) refers to two clinical blood tests used in immunohematology and immunology. These tests are the Direct Coombs test (also known as direct antiglobulin test or DAT) and Indirect Coombs test (also known as indirect antiglobulin test or IAT). The direct Coombs test is used to detect red blood cells sensitized with igG alloantibody, IgG autoantibody, and complement proteins. It detects antibodies bound to the surface of red blood cells in vivo. The red blood cells (RBCs) are washed (removing the patient's own plasma) and then incubated with antihuman globulin (also known as "Coombs reagent"). If this produces agglutination of the RBCs, the direct Coombs test is positive. The indirect Coombs test is used in prenatal testing of pregnant women, and in testing blood prior to a blood transfusion. It detects antibodies against RBCs that are present unbound in the patient's serum. In this case, serum is extracted from the blood, and the serum is incubated with RBCs of known antigenicity. If agglutination occurs, the indirect Coombs test is positive.
Articles this image appears in
Coombs test
Creator
A. Rad
  • Support as nominator ZeWrestler Talk 03:18, 31 October 2007 (UTC)[reply]
  • Oppose - I can't get behind schematics in a bitmap format. Even in cases where the SVG rendering isn't great, we should at least have it available to base PNG exports on. It's very wasteful to create a wonderful diagram like this one in an editable vector format, and then throw all that away by only keeping the PNG on Wikipedia. I see a note on this image's page saying that the author can't do SVG exports. I'd be happy to help in converting the Xara X format to SVG, and then I'd support this nom. --Sean 14:02, 31 October 2007 (UTC)[reply]
    • Can you contact him and ask about that?--ZeWrestler Talk 14:53, 31 October 2007 (UTC)[reply]
    • Hi all, and thanks for the nomination. Unfortunately, X1 indeed can't export to SVG. Xtreme, which is thet latest version of this program can, but the export filter is still underdeveloped according to the developers. Another problem is that SVG (AFAIK) can't handle objects that have blurred edges, like the shadows in this drawing and some of the highlights on the RBCs. I'm happy to help converting this image to SVG. I'll install the trial of Xtreme and see what the SVG export looks like. Sean, thanks for offering your help. I've uploaded the native .xar file here. Xtreme can also do PDF exports, which is reported to be very good according to its users. Maybe a better alternative would be to convert the PDF to SVG. But I don't know whether we'd still suffer the same problems as I mentioned above (with blurred objects). Greets, A. Rad 08:58, 1 November 2007 (UTC)[reply]
      • Hi A. Rad, thanks for chiming in, and for the excellent drawing! I tried XaraLX but was not able to get it converted, so I'm withdrawing my opposition. --Sean 12:53, 1 November 2007 (UTC)[reply]
        • Hey Sean, yeah I tried Xtreme too now, but the SVG was completely bitmap. On the other hand, the PDF looked very good IMO (here). Maybe converting the PDF to SVG would give better results. I don't have any software that can do this though. According to this, only CorelDraw and AI can import pdf and export to svg. Maybe someone who has them can give it a shot. It could give a better result. Greets, A. Rad 17:46, 1 November 2007 (UTC)[reply]
  • Neutral, i'm not too concerned about the picture being PNG and not SVG. However, an expert on the subject will have to confirm the accuracy of the image before i can support it. --Aqwis 22:49, 1 November 2007 (UTC)[reply]
    • It really depends on your definition of "expert" :) When I made the very early version of this pic, User:Snowmanradio gave me a lot of feedback on it. And, at the same time, he (or she) also contributed a lot on the Coombs test article. You can find those discussions on my talk page and the article's. I'm a med student, so not really an expert. You could ask Snowman about his background. I'm open to all feedback from experts ;) For the record, I'm in favour of having this diagram checked by an expert and I've once posted on WikiProject Clinical medicine asking for this, but the responses were a bit limited. BTW, I've now added Snowman to the image's description page. Greets, A. Rad 08:11, 2 November 2007 (UTC)[reply]

No consensus. MER-C 11:18, 7 November 2007 (UTC)[reply]

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