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Icons illustrating symptoms of ME/CFS
Symptoms of ME/CFS

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling chronic illness. People with ME/CFS experience profound fatigue that does not go away with rest, sleep issues, and problems with memory or concentration. The hallmark symptom is a worsening of the illness which starts hours to days after minor physical or mental activity, and lasts from hours to several months. The cause of the disease is unknown. ME/CFS often starts after an infection, and many people fit the ME/CFS diagnostic criteria after contracting long COVID. Diagnosis is based on symptoms because no diagnostic test is available. The illness can improve or worsen over time, but full recovery is uncommon. No therapies or medications are approved to treat the condition, and management is aimed at relieving symptoms. About a quarter of those affected are unable to leave their bed or home. People with ME/CFS often face stigma in healthcare settings, and care is complicated by controversies around the cause and treatments of the illness. (Full article...)

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In chemistry, an amino acid is a molecule containing both amine and carboxyl functional groups. In biochemistry, this term refers to alpha-amino acids with the general formula H2NCHRCOOH, where R is an organic substituent.[1] In the alpha amino acids, the amino and carboxylate groups are attached to the same carbon, which is called the α–carbon. The various alpha amino acids differ in which side chain (R group) is attached to their alpha carbon. They can vary in size from just a hydrogen atom in glycine through a methyl group in alanine to a large heterocyclic group in tryptophan.

Beyond the amino acids that are found in all forms of life, many non-natural amino acids have vital roles in technology and industry. For example, the chelating agents EDTA and nitrilotriacetic acid are alpha amino acids that are important in the chemical industry. (more...)

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Badge from a The Hitchhiker's Guide to the Galaxy video game
Badge from a The Hitchhiker's Guide to the Galaxy video game

November 25: Evacuation Day in New York City (1783)

Stanisław II Augustus, 1764
Stanisław II Augustus, 1764
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Thecacera pennigera

Thecacera pennigera, also known as the winged thecacera, is a species of sea slug in the family Polyceridae. It has a cosmopolitan distribution, being found in temperate waters on either side of the North Atlantic Ocean, in the Mediterranean Sea, around South and West Africa, Brazil, Japan, Korea, Pakistan and more recently in Australia and New Zealand. There is a significant difference in colouring between Atlantic populations and Pacific specimens, however. Thecacera pennigera has a typical adult length between 15 millimetres (0.6 in) and 30 millimetres (1.2 in), featuring a short, wide head with two lateral flaps and two sheathed olfactory organs called rhinophores. The body is wedge shaped, being wide at the front and ending in a slender foot with a lateral keel on either side. The general colour of the body is translucent white and the upper side is covered with orange splotches and small black spots. Like other sea slugs, T. pennigera is a hermaphrodite with internal fertilisation and a mating mechanism whereby pairs of animals exchange packets of sperm. This T. pennigera was photographed in the Mar Piccolo of Taranto, Italy.

Photograph credit: Roberto Strafella

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  1. ^ Proline is an exception to this general formula. It lacks the NH2 group because of the cyclization of the side chain.