WSB1

WSB1
Identifiers
Aliases	WSB1, SWIP1, WSB-1, WD repeat and SOCS box containing 1
External IDs	OMIM: 610091; MGI: 1926139; HomoloGene: 9218; GeneCards: WSB1; OMA:WSB1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	27,315,926 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	79,145,497 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; gastric mucosa; ; lower lobe of lung; ; inferior ganglion of vagus nerve; ; tibial nerve; ; Region I of hippocampus proper; ; tibial arteries; ; canal of the cervix; ; endothelial cell; ; left uterine tube;
	Top expressed in
	medullary collecting duct; ; cumulus cell; ; neural tube; ; dorsomedial hypothalamic nucleus; ; pineal gland; ; vas deferens; ; dermis; ; paraventricular nucleus of hypothalamus; ; ventral tegmental area; ; Gonadal ridge;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; ubiquitin-protein transferase activity;
Cellular component	intracellular anatomical structure; cytosol;
Biological process	protein ubiquitination; intracellular signal transduction; protein polyubiquitination; post-translational protein modification; biological process;
	Sources:Amigo / QuickGO
Orthologs
	26118
	78889
	ENSG00000109046
	ENSMUSG00000017677
	Q9Y6I7
	O54927
	NM_015626; NM_134264; NM_134265; NM_001348350
	NM_001042565; NM_019653
	NP_056441; NP_599027; NP_001335279
	NP_001036030; NP_062627
	Wikidata
View/Edit Human	View/Edit Mouse

WD repeat and SOCS box-containing protein 1 is a protein that in humans is encoded by the WSB1 gene.^[5]^[6]^[7]

This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000109046 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000017677 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vasiliauskas D, Hancock S, Stern CD (Aug 1999). "SWiP-1: novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development". Mech Dev. 82 (1–2): 79–94. doi:10.1016/S0925-4773(99)00014-3. PMID 10354473. S2CID 15357835.
^ Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (Jun 2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
^ ^a ^b "Entrez Gene: WSB1 WD repeat and SOCS box-containing 1".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Kamura T, Burian D, Yan Q, et al. (2001). "Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase". J. Biol. Chem. 276 (32): 29748–53. doi:10.1074/jbc.M103093200. PMID 11384984.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Dentice M, Bandyopadhyay A, Gereben B, et al. (2005). "The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate". Nat. Cell Biol. 7 (7): 698–705. doi:10.1038/ncb1272. PMC 1761694. PMID 15965468.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Woo JS, Imm JH, Min CK, et al. (2006). "Structural and functional insights into the B30.2/SPRY domain". EMBO J. 25 (6): 1353–63. doi:10.1038/sj.emboj.7600994. PMC 1422157. PMID 16498413.
Chen QR, Bilke S, Wei JS, et al. (2006). "Increased WSB1 copy number correlates with its over-expression which associates with increased survival in neuroblastoma". Genes Chromosomes Cancer. 45 (9): 856–62. doi:10.1002/gcc.20349. PMID 16804916. S2CID 3099056.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000109046 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000017677 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10354473-5] Vasiliauskas D, Hancock S, Stern CD (Aug 1999). "SWiP-1: novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development". Mech Dev. 82 (1–2): 79–94. doi:10.1016/S0925-4773(99)00014-3. PMID 10354473. S2CID 15357835.

[pmid12076535-6] Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (Jun 2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.

[entrez-7] "Entrez Gene: WSB1 WD repeat and SOCS box-containing 1".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

References

Further reading