WIPF2

WIPF2
Identifiers
Aliases	WIPF2, WICH, WIRE, WAS/WASL interacting protein family member 2
External IDs	OMIM: 609692; MGI: 1924462; HomoloGene: 15777; GeneCards: WIPF2; OMA:WIPF2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	40,284,136 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	98,795,866 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; buccal mucosa cell; ; frontal pole; ; lower lobe of lung; ; nipple; ; Brodmann area 46; ; internal globus pallidus; ; Brodmann area 10; ; optic nerve; ; paraflocculus of cerebellum;
	Top expressed in
	transitional epithelium of urinary bladder; ; genital tubercle; ; subiculum; ; superior colliculus; ; ventral tegmental area; ; tail of embryo; ; central gray substance of midbrain; ; medial geniculate nucleus; ; Region I of hippocampus proper; ; dorsomedial hypothalamic nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	actin binding; protein binding; actin filament binding;
Cellular component	cytoplasm; cytosol; cytoskeleton; nucleoplasm; plasma membrane; actin filament; actin cortical patch;
Biological process	Fc-gamma receptor signaling pathway involved in phagocytosis; actin cortical patch assembly; endocytosis; actin filament-based movement; positive regulation of actin nucleation; actin cortical patch localization;
	Sources:Amigo / QuickGO
Orthologs
	147179
	68524
	ENSG00000171475
	ENSMUSG00000038013
	Q8TF74
	Q6PEV3
	NM_133264
	NM_197940
	NP_573571
	NP_922922
	Wikidata
View/Edit Human	View/Edit Mouse

WAS/WASL-interacting protein family member 2 is a protein that in humans is encoded by the WIPF2 gene.^[5]^[6]^[7]

This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171475 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038013 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Aspenstrom P (Sep 2002). "The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor". Exp Cell Res. 279 (1): 21–33. doi:10.1006/excr.2002.5576. PMID 12213210.
^ Kato M, Miki H, Kurita S, Endo T, Nakagawa H, Miyamoto S, Takenawa T (Feb 2002). "WICH, a novel verprolin homology domain-containing protein that functions cooperatively with N-WASP in actin-microspike formation". Biochem Biophys Res Commun. 291 (1): 41–7. doi:10.1006/bbrc.2002.6406. PMID 11829459.
^ ^a ^b "Entrez Gene: WIPF2 WAS/WASL interacting protein family, member 2".

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Salazar MA, Kwiatkowski AV, Pellegrini L, et al. (2004). "Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton". J. Biol. Chem. 278 (49): 49031–43. doi:10.1074/jbc.M308104200. PMID 14506234.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171475 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038013 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12213210-5] Aspenstrom P (Sep 2002). "The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor". Exp Cell Res. 279 (1): 21–33. doi:10.1006/excr.2002.5576. PMID 12213210.

[pmid11829459-6] Kato M, Miki H, Kurita S, Endo T, Nakagawa H, Miyamoto S, Takenawa T (Feb 2002). "WICH, a novel verprolin homology domain-containing protein that functions cooperatively with N-WASP in actin-microspike formation". Biochem Biophys Res Commun. 291 (1): 41–7. doi:10.1006/bbrc.2002.6406. PMID 11829459.

[entrez-7] "Entrez Gene: WIPF2 WAS/WASL interacting protein family, member 2".

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References

Further reading