WFIKKN1

WFIKKN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DDI, 2DDJ
Identifiers
Aliases	WFIKKN1, C16orf12, RJD2, WFDC20A, WFIKKN, WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
External IDs	OMIM: 608021; MGI: 2670967; HomoloGene: 14244; GeneCards: WFIKKN1; OMA:WFIKKN1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	634,117 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	26,099,832 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; mucosa of transverse colon; ; right frontal lobe; ; pituitary gland; ; putamen; ; Brodmann area 9; ; anterior cingulate cortex; ; anterior pituitary; ; nucleus accumbens; ; skin of abdomen;
	Top expressed in
	otic vesicle; ; primitive streak; ; embryo; ; somite; ; morula; ; tail of embryo; ; granulocyte; ; embryo; ; blastocyst; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; enzyme inhibitor activity; protein binding; metalloendopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity; receptor antagonist activity; transforming growth factor beta binding;
Cellular component	extracellular region;
Biological process	skeletal system development; negative regulation of DNA binding; roof of mouth development; negative regulation of peptidase activity; negative regulation of protein binding; negative regulation of endopeptidase activity; negative regulation of transforming growth factor beta receptor signaling pathway; extracellular negative regulation of signal transduction; negative regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	117166
	215001
	ENSG00000127578
	ENSMUSG00000071192
	Q96NZ8
	Q8R0S6
	NM_053284
	NM_001100454
	NP_444514
	NP_001093924
	Wikidata
View/Edit Human	View/Edit Mouse

WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 1 is a protein that is encoded by the WFIKKN1 gene.^[5]^[6]^[7] when found in humans.

This gene encodes a secreted multidomain protein consisting of a signal peptide, a WAP domain, a follistatin domain, an immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. These domains have been implicated frequently in inhibition of various types of proteases, suggesting that the encoded protein may be a multivalent protease inhibitor and may control the action of multiple types of serine proteases as well as metalloproteinases.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127578 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000071192 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Trexler M, Banyai L, Patthy L (Mar 2001). "A human protein containing multiple types of protease-inhibitory modules". Proc Natl Acad Sci U S A. 98 (7): 3705–9. Bibcode:2001PNAS...98.3705T. doi:10.1073/pnas.061028398. PMC 31116. PMID 11274388.
^ Trexler M, Banyai L, Patthy L (Apr 2002). "Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules". Biol Chem. 383 (1): 223–8. doi:10.1515/BC.2002.023. PMID 11928817. S2CID 37069938.
^ ^a ^b "Entrez Gene: WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1".

Liepinsh E, Nagy A, Trexler M, et al. (2006). "Second Kunitz-type protease inhibitor domain of the human WFIKKN1 protein". J. Biomol. NMR. 35 (1): 73–8. doi:10.1007/s10858-006-9013-1. PMID 16791741. S2CID 34083234.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Nagy A, Trexler M, Patthy L (2003). "Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein". Eur. J. Biochem. 270 (9): 2101–7. doi:10.1046/j.1432-1033.2003.03593.x. PMID 12709070.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000127578 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000071192 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11274388-5] Trexler M, Banyai L, Patthy L (Mar 2001). "A human protein containing multiple types of protease-inhibitory modules". Proc Natl Acad Sci U S A. 98 (7): 3705–9. Bibcode:2001PNAS...98.3705T. doi:10.1073/pnas.061028398. PMC 31116. PMID 11274388.

[pmid11928817-6] Trexler M, Banyai L, Patthy L (Apr 2002). "Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules". Biol Chem. 383 (1): 223–8. doi:10.1515/BC.2002.023. PMID 11928817. S2CID 37069938.

[entrez-7] "Entrez Gene: WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1".

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References

Further reading