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Vinylacetyl-CoA Delta-isomerase

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Vinylacetyl-CoA Δ-isomerase
Identifiers
EC no.5.3.3.3
CAS no.9023-73-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a vinylacetyl-CoA Delta-isomerase (EC 5.3.3.3) is an enzyme that catalyzes the chemical reaction

vinylacetyl-CoA crotonyl-CoA

Hence, this enzyme has one substrate, vinylacetyl-CoA, and one product, crotonyl-CoA.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is vinylacetyl-CoA Delta3-Delta2-isomerase. Other names in common use include vinylacetyl coenzyme A Delta-isomerase, vinylacetyl coenzyme A isomerase, and Delta3-cis-Delta2-trans-enoyl-CoA isomerase. This enzyme participates in butanoate metabolism.

Structural studies

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As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1U8V.

References

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  • Lynen F, Knappe J, Lorch E, Jutting G, Ringelmann E (1959). "Die biochemische Funktion des Biotins". Angew. Chem. 71 (15–16): 481–486. doi:10.1002/ange.19590711503.
  • Rilling HC; Coon MJ (1960). "The enzymatic isomerization of beta-methylvinylacetyl coenzyme A and the specificity of a bacterial beta-methylcrotonyl coenzyme A carboxylase". J. Biol. Chem. 235 (11): 3087–3092. doi:10.1016/S0021-9258(20)81314-3.