Villoglandular adenocarcinoma of the cervix
| Villoglandular adenocarcinoma of the cervix | |
|---|---|
| Other names | Villoglandular papillary adenocarcinoma, papillary villoglandular adenocarcinoma, well-differentiated villoglandular adenocarcinoma (VGA) |
 | |
| Micrograph of a villoglandular adenocarcinoma the cervix. H&E stain. | |
| Specialty | Pathology, gynecology |
Villoglandular adenocarcinoma of the cervix is a rare type of cervical cancer that, in relation to other cervical cancers, is typically found in younger women and has a better prognosis.[1]
A similar lesion, villoglandular adenocarcinoma of the endometrium, may arise from the inner lining of the uterus, the endometrium.[2]
Signs and symptoms
[edit]The signs and symptoms are similar to other cervical cancers and may include post-coital bleeding and/or pain during intercourse (dyspareunia). Early lesions may be completely asymptomatic.[citation needed]
Cause
[edit]![[icon]](/wiki/File:Wiki_letter_w_cropped.svg){kind=small} | This section is empty. You can help by adding to it. (August 2017) |
Diagnosis
[edit]The diagnosis is based on tissue examination, e.g. biopsy.
The name of the lesion describes it microscopic appearance. It has nipple-like structures with fibrovascular cores (papillae) that are long in relation to their width (villus-like), which are covered with a glandular pseudostratified columnar epithelium.[citation needed]
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Very low magnification -
Intermediate magnification -
Very high magnification
Treatment
[edit]The treatment is dependent on the stage. As the prognosis of this tumour is usually good, fertility sparing approaches (conization, cervicectomy) may be viable treatment options.[citation needed]
See also
[edit]References
[edit]- ^ Korach, J.; Machtinger, R.; Perri, T.; Vicus, D.; Segal, J.; Fridman, E.; Ben-Baruch, G. (2009). "Villoglandular papillary adenocarcinoma of the uterine cervix: a diagnostic challenge". Acta Obstet Gynecol Scand. 88 (3): 355–8. doi:10.1080/00016340902730359. PMID 19172445. S2CID 5835426.
- ^ Zaino, RJ.; Kurman, RJ.; Brunetto, VL.; Morrow, CP.; Bentley, RC.; Cappellari, JO.; Bitterman, P. (Nov 1998). "Villoglandular adenocarcinoma of the endometrium: a clinicopathologic study of 61 cases: a gynecologic oncology group study". Am J Surg Pathol. 22 (11): 1379–85. doi:10.1097/00000478-199811000-00008. PMID 9808130.