Jump to content

VPS33B

From Wikipedia, the free encyclopedia
(Redirected from VPS33B (gene))
VPS33B
Identifiers
AliasesVPS33B, late endosome and lysosome associated, VPS33B late endosome and lysosome associated
External IDsOMIM: 608552; MGI: 2446237; HomoloGene: 10261; GeneCards: VPS33B; OMA:VPS33B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001289148
NM_001289149
NM_018668

NM_178070

RefSeq (protein)

NP_001276077
NP_001276078
NP_061138

NP_835171

Location (UCSC)Chr 15: 91 – 91.02 MbChr 7: 79.92 – 79.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Vacuolar protein sorting-associated protein 33B is a protein that in humans is encoded by the VPS33B gene.[5][6]

Function

[edit]

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.[6]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184056Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030534Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pevsner J, Hsu SC, Hyde PS, Scheller RH (Dec 1996). "Mammalian homologues of yeast vacuolar protein sorting (vps) genes implicated in Golgi-to-lysosome trafficking". Gene. 183 (1–2): 7–14. doi:10.1016/S0378-1119(96)00367-8. PMID 8996080.
  6. ^ a b "Entrez Gene: VPS33B vacuolar protein sorting 33 homolog B (yeast)".

Further reading

[edit]