AP2B1

AP2B1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E42, 2G30, 2IV8, 2IV9, 2JKR, 2JKT, 2VGL, 2XA7, 4UQI
Identifiers
Aliases	AP2B1, ADTB2, AP105B, AP2-BETA, CLAPB1, adaptor related protein complex 2 beta 1 subunit, adaptor related protein complex 2 subunit beta 1
External IDs	OMIM: 601025; MGI: 1919020; HomoloGene: 68176; GeneCards: AP2B1; OMA:AP2B1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q12 Start 35,578,046 bp End 35,726,413 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 C Start 83,189,850 bp End 83,295,861 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone Brodmann area 10 islet of Langerhans stromal cell of endometrium rectum right frontal lobe cingulate gyrus anterior cingulate cortex C1 segment Top expressed in spermatid seminiferous tubule spermatocyte dentate gyrus of hippocampal formation granule cell superior frontal gyrus lateral septal nucleus tail of embryo cerebellar cortex somite subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function clathrin adaptor activity protein-containing complex binding clathrin binding signal sequence binding protein binding cargo receptor activity Cellular component endocytic vesicle membrane cytosol clathrin-coated endocytic vesicle membrane membrane clathrin coat plasma membrane trans-Golgi network endolysosome membrane membrane coat clathrin-coated pit clathrin adaptor complex AP-2 adaptor complex clathrin-coated endocytic vesicle postsynapse glutamatergic synapse Biological process cardiac septum development endocytosis ventricular septum development antigen processing and presentation of exogenous peptide antigen via MHC class II ephrin receptor signaling pathway mitigation of host defenses by virus coronary vasculature development aorta development heart development clathrin-dependent endocytosis clathrin coat assembly protein transport intracellular protein transport vesicle-mediated transport microtubule-based movement Wnt signaling pathway, planar cell polarity pathway membrane organization neurotransmitter receptor internalization low-density lipoprotein particle receptor catabolic process low-density lipoprotein particle clearance transport positive regulation of endocytosis postsynaptic neurotransmitter receptor internalization negative regulation of neuron death positive regulation of protein localization to membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 163 71770 Ensembl ENSG00000006125 ENSMUSG00000035152 UniProt P63010 Q9DBG3 RefSeq (mRNA) NM_001030006 NM_001282 NM_001035854 NM_027915 RefSeq (protein) NP_001025177 NP_001273 NP_001030931 NP_082191 Location (UCSC) Chr 17: 35.58 – 35.73 Mb Chr 11: 83.19 – 83.3 Mb PubMed search
Wikidata
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AP-2 complex subunit beta is a protein that in humans is encoded by the AP2B1 gene.

Function

The protein encoded by this gene is one of two large chain components of the AP2 adaptor complex, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene.

Interactions

AP2B1 has been shown to interact with:

• AP1M2,
• Arrestin beta 2,
• BUB1B,
• LDLRAP1 and
• TGF beta receptor 2.

Further reading

• Kirchhausen T (2000). "Clathrin". Annual Review of Biochemistry. 69: 699–727. doi:10.1146/annurev.biochem.69.1.699. PMID 10966473.
• Geyer M, Fackler OT, Peterlin BM (Jul 2001). "Structure--function relationships in HIV-1 Nef". EMBO Reports. 2 (7): 580–5. doi:10.1093/embo-reports/kve141. PMC 1083955. PMID 11463741.
• Ponnambalam S, Robinson MS, Jackson AP, Peiperl L, Parham P (Mar 1990). "Conservation and diversity in families of coated vesicle adaptins". The Journal of Biological Chemistry. 265 (9): 4814–20. doi:10.1016/S0021-9258(19)34045-1. PMID 1969413.
• Greenberg ME, Bronson S, Lock M, Neumann M, Pavlakis GN, Skowronski J (Dec 1997). "Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation". The EMBO Journal. 16 (23): 6964–76. doi:10.1093/emboj/16.23.6964. PMC 1170300. PMID 9384576.
• Lim DS, Kirsch DG, Canman CE, Ahn JH, Ziv Y, Newman LS, Darnell RB, Shiloh Y, Kastan MB (Aug 1998). "ATM binds to beta-adaptin in cytoplasmic vesicles". Proceedings of the National Academy of Sciences of the United States of America. 95 (17): 10146–51. Bibcode:1998PNAS...9510146L. doi:10.1073/pnas.95.17.10146. PMC 21476. PMID 9707615.
• Greenberg M, DeTulleo L, Rapoport I, Skowronski J, Kirchhausen T (Nov 1998). "A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4". Current Biology. 8 (22): 1239–42. Bibcode:1998CBio....8.1239G. doi:10.1016/S0960-9822(07)00518-0. PMID 9811611. S2CID 14272751.
• Berlioz-Torrent C, Shacklett BL, Erdtmann L, Delamarre L, Bouchaert I, Sonigo P, Dokhelar MC, Benarous R (Feb 1999). "Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins". Journal of Virology. 73 (2): 1350–61. doi:10.1128/JVI.73.2.1350-1361.1999. PMC 103959. PMID 9882340.
• Owen DJ, Vallis Y, Pearse BM, McMahon HT, Evans PR (Aug 2000). "The structure and function of the beta 2-adaptin appendage domain". The EMBO Journal. 19 (16): 4216–27. doi:10.1093/emboj/19.16.4216. PMC 302036. PMID 10944104.
• Fan GH, Yang W, Wang XJ, Qian Q, Richmond A (Jan 2001). "Identification of a motif in the carboxyl terminus of CXCR2 that is involved in adaptin 2 binding and receptor internalization". Biochemistry. 40 (3): 791–800. doi:10.1021/bi001661b. PMC 2664867. PMID 11170396.
• Swigut T, Shohdy N, Skowronski J (Apr 2001). "Mechanism for down-regulation of CD28 by Nef". The EMBO Journal. 20 (7): 1593–604. doi:10.1093/emboj/20.7.1593. PMC 145469. PMID 11285224.
• Laporte SA, Miller WE, Kim KM, Caron MG (Mar 2002). "beta-Arrestin/AP-2 interaction in G protein-coupled receptor internalization: identification of a beta-arrestin binging site in beta 2-adaptin". The Journal of Biological Chemistry. 277 (11): 9247–54. doi:10.1074/jbc.M108490200. PMID 11777907.
• Collins BM, McCoy AJ, Kent HM, Evans PR, Owen DJ (May 2002). "Molecular architecture and functional model of the endocytic AP2 complex". Cell. 109 (4): 523–35. doi:10.1016/S0092-8674(02)00735-3. PMID 12086608. S2CID 483953.
• He G, Gupta S, Yi M, Michaely P, Hobbs HH, Cohen JC (Nov 2002). "ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2". The Journal of Biological Chemistry. 277 (46): 44044–9. doi:10.1074/jbc.M208539200. PMID 12221107.
• Cayrol C, Cougoule C, Wright M (Nov 2002). "The beta2-adaptin clathrin adaptor interacts with the mitotic checkpoint kinase BubR1". Biochemical and Biophysical Research Communications. 298 (5): 720–30. doi:10.1016/S0006-291X(02)02522-6. PMID 12419313.
• Yao D, Ehrlich M, Henis YI, Leof EB (Nov 2002). "Transforming growth factor-beta receptors interact with AP2 by direct binding to beta2 subunit". Molecular Biology of the Cell. 13 (11): 4001–12. doi:10.1091/mbc.02-07-0104. PMC 133610. PMID 12429842.
• Kalthoff C, Groos S, Kohl R, Mahrhold S, Ungewickell EJ (Nov 2002). "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi". Molecular Biology of the Cell. 13 (11): 4060–73. doi:10.1091/mbc.E02-03-0171. PMC 133614. PMID 12429846.

External links

• Human AP2B1 genome location and AP2B1 gene details page in the UCSC Genome Browser.