User talk:Smaug77

Hi, Smaug77.

You wrote:

Hi Paul, You reverted my comments about the genotoxity of TCAs, and said that the srudy was disproven. I looked up the study you talked about. I diod not know this study, so thank you very much. It was very interesting. But to my mind the genotoxity of TCA in Drosophila Melanogaster has not been disproven in this study. The TCAs mentioned are still proven to be genotosic in Drosophila Melanogaster, but it seems that this study found no link between genotoxic TCAs and breast cancer. Thats good news to my mind... but i think it still should be mentioned that these TCAS have been found to be genotoxic. In other countries (such as Germnay) this is mentuioned in the professionals information. to give you an example: [am sorry, it is in German, hope you can understand it]. So i think genotoxity should be mentioned, breast cancer should be not mentioned. How do you think about this. Sorry, english is not my native language :). I hope you understood me nontheless :) Smaug77 —Preceding comment was added at 16:29, 10 November 2007 (UTC)[reply]

The prescribing information you referred me to is uncertain as for the potential mutagenicity of TCA's: "Clomipramin wurde nur unzureichend bezüglich Mutagenität geprüft. Neben negativen In-vitro-Befunden zeigte Clomipramin in Untersuchungen an Drosophila eine mutagene Wirkung. Die Bedeutung dieser Befunde für die klinische Anwendung ist derzeit ungeklärt. In einer Langzeitstudie über 2 Jahre an Ratten ergaben sich keine Hinweise auf eine kanzerogene Wirkung von Clomipramin." You should also remember that the article disproving the breast cancer link appeared at the end of 2006 and the prescribing information has not been updated. The difference between the fruit fly and human is so great that toxicity to flies really does not deserve mentioning, especially since the human results were negative. The mutagenicity in other mammal species appears to be absent as well.Paul gene 21:44, 10 November 2007 (UTC)[reply]