To: MoJohn47

Greetings,

Your comment Weismann-Swim-Hayflick Limit is so good that it deserves to be published as a separate wikipedia entry! Please do this!

Your comment was originally posted by you on August 25, 2010 at: http://en.wikipedia.org/wiki/Talk:Leonard_Hayflick specifically at: http://en.wikipedia.org/w/index.php?title=Talk:Leonard_Hayflick&action=edit&section=3 Good Luck! (Gavrilov (talk) 21:50, 21 August 2011 (UTC))[reply]

August 25, 2010 ====== COMMENT =========

Weismann-Swim-Hayflick Limit The antiquated idea that lifespan might be determined by the limited capacity of somatic cells to divide was originated by the famous German biologist August Weismann in 1892 (1). Mechnikov, who coined the term “gerontology,” discussed Weismann’s theory of cell division limit in his book “Essais optimistes” published in 1907 (2). In the 1950s the first convincing experimental evidence that animal cells in culture cannot be propagated indefinitely was presented by Swim, Parker, and Haff from Western Reserve University School of Medicine (3 – 5), and their results were reproduced by Hayflick and Moorhead in 1961 (6). The popular press has persisted in using the term “The Hayflick Limit” to promote the scientifically naïve idea that the human lifespan is determined by a limited number of cell divisions, although the relevance of finite divisions by fibroblasts in culture to lifespan in an organism, e.g. a person, is highly questionable (7, 8, 9). The observation that many types of cells derived from normal tissue have a finite capacity to divide in culture might be more accurately termed the Weismann-Swim-Hayflick Limit (10). 1. Weismann, A. (1892). Uber Leben und Tod. Verlag von Gustav Fisher, Jena. 2. Mechnikov, I.I. (1907). Essais optimistes. Paris, 438 p. Author: Mechnikov, I. I. (Ilíà Ilich), 1845-1916 Subject: Longévité Publisher: Paris: A. Maloine Language: French; Russian Call number: b1650679 Digitizing sponsor: University of Ottawa Written in French. Titre original: Etiudy optimizma. 3. Haff, R.F. and Swim, H.E. (1956). Serial propagation of 3 strains of rabbit fibroblasts; their susceptibility to infection with Vaccinia virus. Proc.Soc.Exp.Biol.Med., 93, 200-204. 4. Swim, H.E. and Parker, R.F. (1957). Culture characteristics of human fibroblasts propagated serially. Am.J.Hygiene, 66, 235-243. 5. Swim, H.E. (1959). Microbiological aspects of tissue culture. Ann.Rev.Microbiol. 13, 141-176. 6. Hayflick, L., Moorhead, P.S. The serial cultivation of human diploid cell strains. Exp Cell Res. 1961;25:585-621. 7. Rubin H. The disparity between human cell senescence in vitro and lifelong replication in vivo. Nat Biotechnol. 2002 Jul;20(7):675-81. Review. PMID: 12089551 8. Macieira-Coelho A. The implications of the 'hayflick limit' for aging of the organism have been misunderstood by many gerontologists. Gerontology. 1995;41(2):94-7. Review. 1995;41(4):241. PMID: 7744273 9. de Magalhães JP. From cells to ageing: a review of models and mechanisms of cellular senescence and their impact on human ageing. Exp Cell Res. 2004 Oct 15;300(1):1-10. Review.PMID: 15383309 10. Gavrilov, L.A. and Gavrilova, N.S. (1991). The Biology of Life Span: a Quantitative Approach. Harwood Academic Publishers GMBH, Chur, etc. ISBN: 3-7186-4983-7. MoJohn47 (talk) 17:07, 25 August 2010 (UTC)MoJohn — Preceding unsigned comment added by Gavrilov (talk • contribs)