User talk:Matthomas118
Thanks for your insightful suggestions! I reread the sentence about the NET’s role in depression and you were right about it not making sense. The NET is responsible for transporting norepinephrine and other neurotransmitters out of the synapse and therefore decreasing their concentrations in the synapse. When it is blocked by a reuptake inhibitor, the neurotransmitters are instead trapped inside the synapse making the cell response to be more excitatory. I added more information to the ADHD section just to explain how the NET is involved in causing ADHD. It is similar to the role it plays helping to alleviate the symptoms of depression. I could not find a lot of information on the role of NETs in causing schizophrenia because not much research has been devoted to figuring out the mechanism by which it is caused. Also, I included the drugs that are used to combat each type of psychiatric disorder because of its classification under “Therapeutic Uses.”
Stephanie, Normally, the NET functions by transporting the neurotransmitters out of the cell, so if the reuptake medications inhibit the NET, then the neurotransmitters that would normally be taken out side the cell would be trapped inside the synapse. It did not make sense that the extracellular concentrations would be higher during the NET blockade, but it is true that the normal function is inhibited and that the NT levels increase, ultimately stimulating the presynaptic neuron. I am not sure if you read further into the ADHD section, but I had also mentioned other drugs like Methylphenidate and Vyvanse and their corresponding side effects. However, I edited the first sentence, cluing in on that I was going to talk about the other drugs besides atomoxetine.
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