User talk:HelinaSaleh

    I am planning to make some changes and update the info on the Chemogenetics Page and I would kindly appreciate your feed back . I have written the preliminary outline below. Thank you .

       Chemogenetics

        * Indicate the difference between optogenetics and chemogenetics ( i.e., Having more spatiotemporal control . ) Explain how the spatiotemporal control is achieved . 
        * Explain more about the process of designing DREADDs and retro DREADDS.

        Benefits : 
          *Pharmacology and treating different diseases : link the information to the diseases page . The targeted diseases in chemogenetics currently consist of neurodegenerative disorders such as Parkinsons disease and neuropsychological disorders such as addiction and anxiety, depression and Schizophrenia. 
          
          *The advancement of chemogenetics in pain management . ( add osteoarthritis associated pain to the diseases under investigation in this field. )

         Animal Models  : 

        * Advancement and limits : explain non primate models used such as rodent models. Discuss the advancement s and limitation of using non human primate models.

        Future Direction : 
      
         * discuss the future directions considered in the literature and how chemogenetics can be incorporated to treat different disorders. HelinaSaleh (talk) 21:24, 11 May 2017 (UTC)[reply]

       References so far include : 
    1. Galvan, Adriana; Caiola, Michael J.; Albaugh, Daniel L. (2017-02-25). "Advances in optogenetic and chemogenetic methods to study brain circuits in non-human primates". Journal of Neural Transmission: 1–17. doi:10.1007/s00702-017-1697-8. ISSN 0300-9564.

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     2. ^ Dobrzanski, Grzegorz; Kossut, Małgorzata (2017-04-01). "Application of the DREADD technique in biomedical brain research". Pharmacological Reports. 69 (2): 213–221. doi:10.1016/j.pharep.2016.10.015.

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       3.^ Bang, Juwon; Kim, Hak Yeong; Lee, Hyosang. "Optogenetic and Chemogenetic Approaches for Studying Astrocytes and Gliotransmitters". Experimental Neurobiology. 25 (5). doi:10.5607/en.2016.25.5.205. PMC 5081467 Freely accessible. PMID 27790055.

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        4.^ Miller, Rachel E.; Ishihara, Shingo; Bhattacharyya, Bula; Delaney, Ada; Menichella, Daniela M.; Miller, Richard J.; Malfait, Anne-Marie (2017-04-01). "Chemogenetic inhibition of pain neurons in a mouse model of osteoarthritis". Arthritis & Rheumatology: n/a–n/a. doi:10.1002/art.40118. ISSN 2326-5205.

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          5.^ Fleury Curado, Thomaz; Fishbein, Kenneth; Pho, Huy; Brennick, Michael; Dergacheva, Olga; Sennes, Luiz U.; Pham, Luu V.; Ladenheim, Ellen E.; Spencer, Richard (2017-03-10). "Chemogenetic stimulation of the hypoglossal neurons improves upper airway patency". Scientific Reports. 7. doi:10.1038/srep44392. ISSN 2045-2322. PMC 5345079 Freely accessible. PMID 28281681.