User talk:Chrisfoo42/sandbox
11/4/15 The intended focus of our edits was to
1) verify the authenticity of information provided in the original article on sulfamethazole, specifically the introduction, side effects, and mechanism of action
2) clarify that sulfamethazole is discontinued as a drug
3) provide a more relevant overview of the drug given it is discontinued as a single drug but still being marketed and used as part of a combination drug product but without overlapping too much on the wiki entry on the combination drug Bactrim
4) provide the above information based on what intel that could be reliably found given the prescribing information for sulfamethazole us no longer attainable from the manufacturer or the FDA since it is a discontinued drug and given that paid tertiary resources like Lexi-comp and Micromedex were not acceptable for this assignment. Futhermore, we understood that compendia like Lexi-comp and Micromedex, were not original sources of drug information (since they derive much of their information usually by reinterpreting the PI) and therefore would not be the best source of information on this drug. We felt a package insert (PI) on the drug or even deriving information on the sulfamethazole API (active pharmaceutical ingredient) from the combination drug Bactrim's PI would be better since it is a primary resource or rather an original source of information. We also referenced NIH sponsored websites such as Toxnet which containing well referenced primary research and Pubchem. We also used information from a Canadian government sponsored drug database named drugbank and also double-checked if the FDA website had any additional information on sulfamethazole.
5) add a pharmacokinetics (PK) overview to the drug since PK is an important aspect of all drugs and this section was missing"
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