User talk:Blb6175535/sandbox

Peer Reviews

Can't wait to peer review this, the topic looks interesting! I'd especially like to see any mathematical models of the catch bonds. Let me know when you add more to it! Abw20 (talk) 05:30, 8 November 2016 (UTC)

Again, I'm excited to read about this when you get some information going! Don't forget, you need five primary source/review articles, so make sure to get at least one more!Abw20 (talk) 06:45, 23 November 2016 (UTC)

Awesome job! I felt like the sections you added (I'm assuming the parts you added were the bolded parts) were very understandable for the general reader, and the figures you added were very simple and easy to understand as well. Here are a couple things you may want to consider: 1) linking the word "shear stress" or "shear-threshold phenomenon." If you look at the page on shear stress and it seems really confusing or really hard to apply to biology for the average reader, maybe you could just throw in a few sentences here explaining it. 2) Other words to link: hydrodynamic drag, tension, allosteric, 3) One sentence that was already there - under teh "leukocytes adhesion mediated by shear stress" section - says that selectin does not exhibit "'true' catch bond property." The rest of "Types section" kind of builds up selectin an leukocytes as the perfect model of catch bonds. This is a little confusing to me. You may want to add something that explains what a true catch bond is and also show us how similar it actually is to a "true" catch bond - because it is what it seems like you are arguing. 4) It would be awesome if you could get some actual figures from the articles - a couple showing the catch-slip transition, and maybe another one that shows the x-ray crystallography picture of the two different confomations of selectin. 5) It would really help if you had another figure to go along with the sliding-rebinding model. Mcfall2016 (talk)