User:WucCP133/sandbox
Pharmacology
[edit]Primaquine is a quinine antimalarial and therefore shares similar properties to quinine. The exact mechanism of action is still unknown, but generally, like most quinine antimalarials, primaquine disrupts hemazoin crystallization in the food vacuole of malaria-causing parasites.
Pharmacokinetics
[edit]Primaquine is well-absorbed in the gut and extensively distributed in the body. With a half-life on the order of 6 hours, it is quickly metabolized by liver enzymes to carboxyprimaquine, which does not have anti-malarial activity. Renal excretion is limited.
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