User:Wikiedit116/C13orf42
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(C13orf42) is a protein which, in humans, is encoded by the gene chromosome 13 open reading frame 42 (C13orf42). C13orf42 is also known by its aliases LINC00371 and LINC00372.[1] Transcript variant 3 is the longest mRNA transcript at 3075 nucleotides.[2] The gene encodes a 325 amino acid protein. This gene has orthologs in mammals, birds, reptiles, amphibians, bony fish, and cartilaginous fish.[3]
Gene
[edit]Location
[edit]C13orf42 is located at 13q14.3 on the minus strand. C13orf42 spans 118,134 base pairs.[1][4]
Aliases
[edit]C13orf42 is also known by its aliases LINC00371 and LINC00372.[1]
Exons
[edit]C13orf42 transcript variant 3 (Accession number: NM_001351589.3) contains 4 exons.[2]
Protein
[edit]Isoforms
[edit]There are two known proteins encoded by the isoforms of C13orf42.[5]
Variant 3
[edit]Transcript variant 3 encodes the longest protein at 325 amino acids long.[5]
Variant X1
[edit]Transcript variant X1 encodes a 189 amino acid long protein.[5]
Homology
[edit]
Orthologs
[edit]C13orf42 has orthologs in mammals, birds, reptiles, amphibians, bony fish, and cartilaginous fish as shown in the table below. No orthologs were found in jawless fish, invertebrates, plants, fungi, viruses, or bacteria.[6] All mammals contain the same 4 exons as the human C13orf42 protein, and nonmammals are missing exon 4.
Ortholog Table
[edit]| Genus and Species | Common Name | Taxonomic Class | Date of Divergence (MYA) | Accession Number | Length (amino acids) | Percent Identity to Homo sapiens | Percent Similarity to Homo sapiens |
|---|---|---|---|---|---|---|---|
| Homo sapiens | Human | Primates | 0 | NP_001338518.1 | 325 | 100 | 100 |
| Mus musculus | Mouse | Dasyuromorphia | 87 | XP_030104110.1 | 318 | 76.9 | 84 |
| Tursiops truncatus | Common bottlenose dolphin | Cetacea | 94 | XP_033699576.1 | 319 | 82.8 | 87.7 |
| Equus caballus | Horse | Perissodactyla | 94 | XP_023477317.1 | 326 | 82.6 | 90.2 |
| Mustela putorius | European polecat | Carnivora | 94 | XP_004775284.1 | 326 | 79.4 | 85 |
| Pipistrellus kuhlii | Kuhl's pipistrelle (bat) | Chiroptera | 94 | XP_036312978.1 | 325 | 79.1 | 86.8 |
| Ursus maritimus | Polar bear | Ursidae | 94 | XP_040478472.1 | 328 | 77.2 | 82.7 |
| Elephas maximus indicus | Indian elephant | Proboscidea | 99 | XP_049709344.1 | 326 | 79.4 | 86.2 |
| Dasypus novemcinctus | Nine-banded armadillo | Cingulata | 99 | XP_023446856.1 | 328 | 72.8 | 81.4 |
| Dromiciops gliroides | Monito del monte | Microbiotheria | 160 | XP_043849658.1 | 326 | 67.9 | 79.5 |
| Trichosurus vulpecula | Common brushtail possum | Diprotodontia | 160 | XP_036599801.1 | 326 | 66.7 | 79.5 |
| Sarcophilus harrisii | Tasmanian devil | Dasyuromorphia | 160 | XP_023355407.1 | 326 | 66.4 | 80.1 |
| Ornithorhynchus anatinus | Playtpus | Monotremes | 180 | XP_028904285.1 | 330 | 62.3 | 73 |
| Alligator sinensis | Chinese alligator | Crocodilian | 319 | XP_025062978.1 | 266 | 48.6 | 61.7 |
| Dromaius novaehollandiae | Emu | Casuariiformes | 319 | XP_025964173.1 | 268 | 48.2 | 59.8 |
| Gallus gallus | Chicken | Galliformes | 319 | XP_004938779.1 | 268 | 47.6 | 61.3 |
| Camarhynchus parvulus | Small tree finch | Thraupidae | 319 | XP_030802909.1 | 264 | 47.1 | 60.9 |
| Pelodiscus sinensis | Chinese softshell turtle | Testudines | 319 | XP_014429996.1 | 267 | 47 | 60.6 |
| Phasianus colchicus | Common pheasant | Galliformes | 319 | XP_031471701.1 | 272 | 46.4 | 59.9 |
| Varanus komodoensis | Komodo dragon | Squamata | 319 | XP_044300138.1 | 269 | 45.9 | 60.1 |
| Python bivittatus | Burmese python | Squamata | 319 | XP_025026122.1 | 269 | 44.1 | 58 |
| Pantherophis guttatus | Corn snake | Squamata | 319 | XP_034287884.1 | 267 | 42.7 | 56.4 |
| Rhinatrema bivittatum | Two-lined caecilian | Rhinatrematidae | 353 | XP_029459031.1 | 273 | 45.4 | 59.5 |
| Xenopus tropicalis | Western clawed frog | Anura | 353 | XP_031752228.1 | 260 | 43.5 | 57.4 |
| Bufo gargarizans | Asiatic toad | Anura | 353 | XP_044141363.1 | 262 | 40.7 | 56.8 |
| Bufo bufo | Common toad | Anura | 353 | XP_040278366.1 | 391 | 30.9 | 42 |
| Protopterus annectens | West african lungfish | Lepidosireniformes | 408 | XP_043927617.1 | 269 | 37.8 | 53.5 |
| Polyodon spathula | Paddlefish | Acipenseriformes | 431 | XP_041127510.1 | 275 | 33.8 | 52.4 |
| Danio rerio | Zebrafish | Cypriniformes | 431 | XP_021329868.1 | 287 | 30.2 | 44.7 |
| Clupea harengus | Atlantic herring | Clupeiformes | 431 | XP_042559186.1 | 306 | 29 | 41.7 |
| Callorhinchus milii | Australian ghostshark | Chimaeriformes | 464 | XP_042189981.1 | 267 | 35.5 | 53.3 |
| Amblyraja radiata | Thorny skate | Rajiformes | 464 | XP_032889397.1 | 267 | 33 | 47.5 |
| Scyliorhinus canicula | Small-spotted catshark | Carcharhiniformes | 464 | XP_038658253.1 | 264 | 32.5 | 50.4 |
Research
[edit]References
[edit]- ^ a b c "C13orf42 chromosome 13 open reading frame 42 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov.
- ^ a b "Homo sapiens chromosome 13 open reading frame 42 (C13orf42), transcript variant 3, mRNA". NCBI nucleotide. 11 June 2022.
- ^ "C13orf42 BLAST: Basic Local Alignment Search Tool". blast.ncbi.nlm.nih.gov.
- ^ "C13orf42 Gene - GeneCards | CM042 Protein | CM042 Antibody". www.genecards.org.
- ^ a b c d "Home - Protein - NCBI". www.ncbi.nlm.nih.gov.
- ^ "Protein BLAST: search protein databases using a protein query". blast.ncbi.nlm.nih.gov.
- ^ "EMBOSS Needle < Pairwise Sequence Alignment < EMBL-EBI". www.ebi.ac.uk.