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Detroit (/dɛ ˈtrɔɪt/) is the largest city in the U.S. state of Michigan and the seat of Wayne County. Detroit is a major port city on the Detroit River, in the Midwest region of the United States. Located north of Windsor, Ontario, Detroit is the only major U.S. city that looks south to Canada. It was founded on July 24, 1701, by the Frenchman Antoine de la Mothe Cadillac. Its name originates from the French word détroit (pronounced [detʁwa] ) for strait, characterizing its location on the river connecting the Great Lakes.