User:Tnzhou

Suggested Edits

Peer Review by  Untediousness

You should link G-protein coupled-receptor!

Also, for convention sake, is it IL-8R alpha or A? Same thing for IL-8R beta or B? I know it might not sound too different but the "types" section uses alpha and beta not A and B. 

Sentence structure: 

"There are two receptors with this name: interleukin-8 receptor A (IL-8RA) and interleukin-8 receptor B (IL-8RB)"

--> You can get rid of this sentence by fusing with the first sentence:

The interleukin-8 receptors (IL-8R) are composed of two 7-transmembrane proteins in the G-protein coupled-receptor family[1]: interleukin-8 receptor A (IL-8RA) and interleukin-8 receptor B (IL-8RB).

You can also get rid of "with presence of" on the third sentence. The sentence works with just "(approximately 65,000 receptors per neutrophil)."

If the information is available, talking about the site of glycosylation may be useful. 

I am not quite understanding what this sentence means:

"Interleukin-8 receptors are interleukin receptors of the chemokine receptor type." What is a chemokine receptor type? Explaining the function as a chemokine receptor would be better. 

The last sentence of the overview is contradicting itself. Is the sentence trying to say that IL-8 binding is lower when other molecules are bound or is it still the same throughout regardless of other molecules binding?

A little bit confused about "7 alpha helices that each span the length of the phospholipid bilayer of a cell membrane." Is this true? Each alpha helices is as long as phospholipid bilayer of a cell membrane? Do you mean the width or the thickness of the membrane?

Isn't 'chromosome 2q35' a locus of gene? Or is it okay to say chromosome 2q35?

Source needed for this claim: "The close proximity and location of these two genes on the chromosome suggest that they have risen from the same ancestor sequence."

Having a rough diagram, even if it is sketched, would be really nice to help visualizing this: "Asp11 on the N-terminus, Glu275 and Arg280 (both on the loop between the 7th and 6th transmembrane domains)." 

"three main peptide residues that participate in ligand binding on IL-8A" --> What about IL-8B? Also it would be great to have citation for thiThe last sentence on C-terminus activity is a bit too long. Perhaps breaking the sentence down into 2 separate sentences would be easier for the readers to read. 

I think it would be best to break up the sentence using the colon. There is too much content in this specific sentence. Differentiate sentence structure because listing the functions here actually is too much to read. So have a sentence for shape/conformational changes, another sentence for degranulation, and the last function. Also don't use 7TM if you haven't abbreviated like that from above. If you want to use this, please do abbreviate it the first time the word comes up. What I'm saying is like: 7-transmembrane (7TM). A source for function would be great for this paragraph.

Overall, great work for adding much more new things to this article. Hopefully the comments are helpful and you can make the article even better! Let me know if you don't understand some of the comments I have made. Obviously there would be some stylistic differences we have. Untediousness (talk) 15:54, 1 June 2017 (UTC)

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Peer Review by User:PrasannR

Instead of listing out my comments like Ted did above, I decided to create a Google Docs version of your article and leave my comments there, so please look over my comments on your article here: https://docs.google.com/document/d/1Hr1wb_OYV8GIdshGZRfHMBK_q1ghZXaF9t_LV8aW248/edit?usp=sharing

Hope that makes my comments/edits easier to understand! PrasannR (talk) 20:08, 1 June 2017 (UTC)

Projects

Article Projects

Interleukin-8 receptor

Possible edits:

-Protein Profile and Introduction: Include a computer-generated image of protein, protein size (kD), subunits, active site(s), binding site(s), ligands, protein type, where it can be found and on which cells it can be found

-Section: "Ligands and Binding Specificity"-- CXCR binds with high affinity to Interleukin 8, but is also respondent to other ligands; elaboration on biochemistry of binding and effects of binding of ligands to CXCR, affinity for other cytokines aside from CXC

-Section: "Pathways in Immunity and Inflammation"--elaboration on how CXCR recruits neutrophils via chemokine interactions to induce inflammatory response in various types of tissue. Discuss the receptors role as a kinase and what it does to activate other kinases

-Section: "Pathways in Cancer and Angiogenesis" -- CXCR is known to be in involved with the pathogenesis and angiogenesis of particular cancers and tumors alongside its corresponding ligand, CXC (Interleukin 8). Discussion about the expression of CXCR in tumors as well as its role in inducing the development of blood vessels

-Section: "Similarities and Differences between Interleukin-8-Receptor (Alpha) and Interleukin-8-Receptor (Beta)" -- discussion of each receptors functions, ligands, and the similarities and differences between the two receptors. Discussion about independent function and differing affinities for ligands.

Link to Presentation

• https://docs.google.com/presentation/d/1MkyzZgPBWpDsAgV-BUXCPvJGYIs2uoj3oeuO5OI-Gaw/edit?usp=sharing

Peer Reviews

• Plastoquinone by User:JAxolotl
• Cross-link by User:Jukakim

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Interleukin-8 receptor

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