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Cited Articles - Protein Biomarkers for the Diagnosis of Alzheimer's Disease

The ability to treat Alzheimer's disease is greatly hindered by the lack of sensitive and specific diagnostic tools. Traditional diagnostic methods have an average accuracy of 70 to 80%, while others cannot definitively provide a diagnosis until post-mortem neuropathological tissue analysis. There is a hotbed of research being conducted to change this bleak landscape for the growing number of people inflicted with the debilitating neurodegenerative disease. Based on the pathophysiology of the disease, a more sensitive diagnostic would be able to identify the disease 10 to 15 years before patients begin presenting with clinical symptoms. A recent study aimed at developing an early diagnostic tool identified a panel of 37 protein biomarkers in cerebrospinal fluid that was able to improve the specificity of diagnosis of Alzheimer's disease when combined with established tau/amyloid-β42 ratios.

Summary of Characteristics of Target Article

In this course, we'll be working a stub article to the status of a B class or GA (Good Article).

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