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Daniel Siebert Speaks Interviewed by Will Beifuss. The Entheogen Review. Vol. 8 No. 3, Autumn 1999.

The History of the First Salvia divinorum Plants Cultivated Outside of Mexico by Daniel Siebert. The Entheogen Review. Vol. 12 No. 4, Winter 2003.

Salvinorin A: The ‘Magic Mint’ Hallucinogen Finds a Molecular Target in the Kappa Opioid Receptor by Sheffler DJ and Roth BL. Trends in Pharmacological Sciences. Vol.24 No.3 March 2003.

Salvinorin A: A Novel and Highly Selective Kappa-Opioid Receptor Agonist by Yan F and Roth BL. Life Sciences. Vol.75 No.22 (2004).

Salvinorin A: From Natural Product to Human Therapeutics by Vortherms TA and Roth BL. Molecular Interventions. Vol.6 No.5 (2006).

Differential Helical Orientations Among Related G Protein-Coupled Receptors Provide a Novel Mechanism for Selectivity: Studies with Salvinorin A and the Kappa-Opioid Receptor by Vortherms TA, Mosier PD, Westkaemper RB, Roth BL.Journal of Biological Chemistry. 282(5): 3146–3156 (2007).

Acute Physiologic and Chronic Histologic Changes in Rats and Mice Exposed to the Unique Hallucinogen Salvinorin A by Mowry M, Mosher M, Briner W. Journal of Psychoactive Drugs. 35(3): 379–382 (2003).

The Plant-Derived Hallucinogen, Salvinorin A, Produces Kappa-Opioid Agonist-like Discriminative Effects in Rhesus Monkeys by Butelman E, Harris T, and Kreek MJ. Psychopharmacology (Berl). 172(2): 220–224 (2004).

Effects of Salvinorin A, a Kappa-Opioid Hallucinogen, on a Neuroendocrine Biomarker Assay in Nonhuman Primates With High Kappa-Receptor Homology to Humans by Butelman ER, Mandau M, Tidgewell K, Prisinzano TE, Yuferov V, Kreek MJ.Journal of Pharmacology and Experimental Therapeutics. 320(1): 300–306 (2007).

A Mazatec girl preparing Salvia divinorum leaves on a metate Photo taken in 1962 by R. Gordon Wasson

Salvinorin, A New trans-Neoclerodane Diterpene from Salvia divinorum (Labiatae) by Ortega A, Blount JF, Manchand PS. Journal of the Chemical Society Perkins Transactions I (1982).

Ethnopharmacology of Ska Maria Pastora (Salvia divinorum, Epling and Játiva-M.) by L.J. Valdés J III, et al. Journal of Ethnopharmacology (1983).

Etnofarmacologia di Ska Maria Pastora (Salvia divinorum, Epling and Játiva-M.) An Italian translation of the above.

Divinorin A, a Psychotropic Terpenoid, and Divinorin B from the Hallucinogenic Mexican Mint, Salvia divinorum by L.J. Valdés III, et al. Journal of Organic Chemistry (1984).

Loliolide from Salvia divinorum by L.J. Valdés III. Journal of Natural Products (1986).

Studies of Salvia divinorum (Lamiaceae), an Hallucinogenic Mint from the Sierra Mazateca in Oaxaca, Central Mexico by L.J. Valdés III, et al. Economic Botany (1987).

Salvia divinorum and the Unique Diterpene Hallucinogen, Salvinorin (Divinorin) A by L.J. Valdés III. Journal of Psychoactive Drugs (1994).

"Divinorin C," a New Neoclerodane Diterpene from a Bioactive TLC Fraction of Salvia divinorum. Lab notes from the desk of L. J. Valdés III. The Salvia divinorum Research and Information Center (2000).

Salvinorin C, a New Neoclerodane Diterpene from a Bioactive Fraction of the Hallucinogenic Mexican Mint Salvia divinorum. by L.J. Valdés III, et al. Organic Letters (2001).

The Early History of Salvia divinorum. by L. J. Valdés III. The Entheogen Review (2001) X(2): [73-75]Some photos of Salvia divinorum from the Sierra Mazateca. by L.J. Valdés III

The Absolute Stereochemistry of Salvinorins Also available in PDF format here. by Koreeda, M., et al. Chemistry Letters (1990).

Kappa-Opioid Receptor-Mediated Effects of the Plant-Derived Hallucinogen, Salvinorin A, on Inverted Screen Performance in the Mouse by Fantegrossi WE, Kugle KM, Valdιs LJ III, Koreeda M, Woods JH. Behavioural pharmacology. 16(8): 627-633 (2005).

Studies Toward the Pharmacophore of Salvinorin A, a Potent Kappa Opioid Receptor Agonist And supporting information by Munro T, Rizzacasa M, Roth BL, Toth B, Yan F Journal of Medicinal Chemistry. 48(2): 345–348 (2005).

Autoxidation of Salvinorin A under Basic Conditions And supporting information by Munro T, Goetchius G, Roth BL, Vortherms T, Rizzacasa M. Journal of Organic Chemistry. 70(24): 10057-10061 (2005).

8-epi-Salvinorin B: Crystal Structure and Affinity at the Kappa Opioid Receptor by Munro TA, Duncan KK, Staples RJ, Xu W, Liu-Chen LY, Beguin C, Carlezon WA Jr, Cohen BM. Beilstein Journal of Organic Chemistry. Epub ahead of print (2007).

The Chemistry of Salvia divinorum. by Thomas Munro. PhD dissertation. This is a large (283 pages - 6.32 MB) PDF document.

Use of Nonprohibited Hallucinogenic Plants: Increasing Relevance for Public Health?

A case report and literature review on the consumption of Salvia divinorum (Diviner's Sage) by Bόcheler R, Gleiter CH, Schwoerer P, and Gaertner I. Pharmacopsychiatry. 38(1): 1–5 (2005).

A Facile Method for the Preparation of Deuterium Labeled Salvinorin A: Synthesis of [2,2,2-2H3-Salvinorin A ] by Kevin Tidgewell, Wayne W. Harding, Mark Schmidt, Kenneth G. Holden, Daryl J. Murry, and Thomas E. Prisinzano. Bioorganic and Medicinal Chemistry Letters. 14(20): 5099-5102 (2004).

Salvinicins A and B, New Neoclerodane Diterpenes from Salvia divinorum. by Harding WW, Tidgewell K, Schmidt M, Shah K, Dersch CM, Snyder J, Parrish D, Deschamps JR, Rothman RB, Prisinzano TE. Organic Letters. 7(14): 3017–3020 (2005).

Neoclerodane Diterpenes as a Novel Scaffold for Mu Opioid Receptor Ligands by Harding WW, Tidgewell K, Byrd N, Cobb H, Dersch CM, Butelman ER, Rothman RB, Prisinzano TE. Journal of Medicinal Chemistry. 48(15): 4765–4771 (2005).

An Opioid Agonist That Does Not Induce Mu-Opioid Receptor–Arrestin Interactions or Receptor Internalization by

Groer CE, Tidgewell K, Moyer RA, Harding WW, Rothman RB, Prisinzano TE, Bohn LM. Molecular Pharmacology. 71(2): 549–557 (2007).

Salvinorin A: Allosteric Interactions at the Mu-Opioid Receptor by Rothman RB, Murphy DL, Xu H, Godin JA, Dersch CM, Partilla JS, Tidgewell K, Schmidt M, Prisinzano TE. Journal of Pharmacology and Experimental Therapeutics. 320(2): 801–810 (2007).

Determination of Salvinorin A in Body Fluids by High Performance Liquid Chromatography-Atmospheric Pressure Chemical Ionization by Schmidt MS, Prisinzano TE, Tidgewell K, Harding W, Butelman ER, Kreek MJ, and Murry DJ. Journal of Chromatography. B. 818(2): 221–225 (2005).

Pharmacokinetics of the Plant-Derived Kappa-Opioid Hallucinogen Salvinorin A in Nonhuman Primates by Schmidt MD, Schmidt MS, Butelman ER, Harding WW, Tidgewell K, Murry DJ, Kreek MJ, Prisinzano TE. Synapse. 58(3): 208–210 (2005).

Psychopharmacology of the Hallucinogenic Sage Salvia divinorum. by Prisinzano TE. Life Sciences. 78(5): 527-531 (2005).

Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Semisynthesis of Salvinicins A and B and Other Chemical Transformations of Salvinorin A by Harding WW, Schmidt M, Tidgewell K, Kannan P, Holden KG, Gilmour B, Navarro H, Rothman RB, Prisinzano TE. Journal of Natural Products. 69(1): 107–112 (2006).

Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Selective Modification of the Furan Ring by Harding WW, Schmidt M, Tidgewell K, Kannan P, Holden KG, Dersch CM, Rothman RB, Prisinzano TE. Bioorganic & Medicinal Chemistry Letters. 16(12): 3170–3174.

Synthesis of Salvinorin A Analogues as Opioid Receptor Probes by Tidgewell K, Harding WW, Lozama A, Cobb H, Shah K, Kannan P, Dersch CM, Parrish D, Deschamps JR, Rothman RB, Prisinzano TE. Journal of Natural Products. 69(6): 914–918 (2006).

Neo-clerodane Diterpenes from the Hallucinogenic Sage Salvia divinorum. And errata by Shirota O, Nagamatsu K, Sekita S. Journal of Natural Products. 69(12): 1782–1786. (2006).

Quantification of the Plant-Derived Hallucinogen Salvinorin A in Conventional and Non-Conventional Biological Fluids by gas chromatography/mass spectrometry after Salvia divinorum smoking by Pichini S, Abanades S, Farre M, Pellegrini M, Marchei E, Pacifici R, Torre RD, and Zuccaro P. Rapid Communications in Mass Spectrometry. 19(12): 1649–1656 (2005).

Synthesis and In Vitro Pharmacological Evaluation of Salvinorin A Analogues Modified at C(2) by Beguin C, Richards MR, Wang Y, Chen Y, Liu-Chen LY, Ma Z, Lee DY, Carlezon WA Jr, and Cohen BM. Bioorganic and Medicinal Chemistry Letters. 15(11): 2761–2765 (2005).

Synthesis and In Vitro Pharmacological Studies of New C(2) Modified Salvinorin A Analogues by Lee DY, Karnati VV, He M, Liu-Chen LY, Kondareti L, Ma Z, Wang Y, Chen Y, Beguin C, Carlezon WA Jr, Cohen B. Bioorganic and Medicinal Chemistry Letters. 15(16): 3744–3747 (2005).

Synthesis and In Vitro Pharmacological Studies of C(4) Modified Salvinorin A Analogues by Lee DY, He M, Kondaveti L, Liu-Chen LY, Ma Z, Wang Y, Chen Y, Li JG, Beguin C, Carlezon WA Jr, Cohen B. Bioorganic and Medicinal Chemistry Letters. Jul 25, 2005 [Epub ahead of print].

New Neoclerodane Diterpenoids Isolated From the Leaves of Salvia divinorum and Their Binding Affinities for Human Kappa Opioid Receptors by Lee DY, Ma Z, Liu-Chen LY, Wang Y, Chen Y, Carlezon WA Jr, Cohen B. Bioorganic and Medicinal Chemistry Letters. Aug 3, 2005 [Epub ahead of print].

Synthesis and In Vitro Pharmacological Studies of New C(4)-Modified Salvinorin A Analogues by Lee DY, He M, Liu-Chen LY, Wang Y, Li JG, Xu W, Ma Z, Carlezon WA Jr, Cohen B Bioorganic and Medicinal Chemistry Letters. 16(21): 5498–5502 (2006).

Depressive-like Effects of the Kappa-Opioid Receptor Agonist Salvinorin A on Behavior and Neurochemistry in Rats by Carlezon Jr WA, Beguin C, Dinieri JA, Baumann MH, Richards MR, Todtenkopf MS, Rothman RB, Ma Z, Lee DY, Cohen BM. Journal of Pharmacology and Experimental Therapeutics. 316(1): 440–447 (2006).

Synthesis and In Vitro Evaluation of Salvinorin A Analogues: Effect of Configuration at C(2) and Substitution at C(18) by Beguin C, Richards MR, Li JG, Wang Y, Xu W, Liu-Chen LY, Carlezon WA Jr, Cohen BM. Bioorganic and Medicinal Chemistry Letters. 16(17): 4679–4685 (2006).

Identification of the Molecular Mechanisms by Which the Diterpenoid Salvinorin A Binds to Kappa-Opioid Receptors by Yan F, Mosier PD, Westkaemper RB, Stewart J, Zjawiony JK, Vortherms TA, Sheffler DJ, Roth BL. Biochemistry. 44(24): 8643–8651 (2005).

Studies Towards the Synthesis of Salvinorin A by Lingham AR, Hόgel HM, Rook TJ. Australian Journal of Chemistry. 59(5): 340–348 (2006).

Determination of Salvinorins and Divinatorins in Salvia divinorum Leaves by Liquid Chromatography/Multistage Mass Spectrometry by Medana C, Massolino C, Pazzi M, Baiocchi C. Rapid Communications in Mass Spectrometry. 20(2): 131–136 (2005).

Analysis of the Psychoactive Terpenoid Salvinorin A Content in Five Salvia divinorum Herbal Products. by Wolowich WR, Perkins AM, Cienki JJ. Pharmacotherapy. 26(9): 1268–1272(2006).

The Antinociceptive Effect of Salvinorin A in Mice by Trentini, John F., Larry G. French, and Joseph S. Erlichman. European Journal of Pharmacology. 545 (2–3): 129–133 (2006).

Antinociceptive Profile of Salvinorin A, a Structurally Unique Kappa Opioid Receptor Agonist by McCurdy CR, Sufka KJ, Smith GH, Warnick JE, Nieto MJ. Pharmacology, Biochemistry, and Behavior. [Epub ahead of print Jan 20, 2006].

A Unique Binding Epitope for Salvinorin A, a Non-Nitrogenous Kappa Opioid Receptor Agonist by Kane BE, Nieto MJ, McCurdy CR, Ferguson DM.FEBS Journal. 273(9): 1966–1974 (2006).

A Combined Ligand-Based and Target-Based Drug Design Approach for G-Protein Coupled Receptors:

Application to Salvinorin A, a Selective Kappa Opioid Receptor Agonist by Singh N, Chevé G, Ferguson DM, McCurdy CR.Journal of Computer-Aided Molecular Design. 20(7–8): 471–493 (2006).

PCR and PCR-RFLP of the 5S-rRNA-NTS Region and Salvinorin A Analyses for the Rapid and Unequivocal Determination of Salvia divinorum. by Bertea CM, Luciano P, Bossi S, Leoni F, Baiocchi C, Medana C, Azzolin CM, Temporale G, Lombardozzi MA, Maffei ME. Phytochemistry. 67(4): 371–378 (2006).

Hallucinatory and Rewarding Effect of Salvinorin A in Zebrafish: Kappa-Opioid and CB1-Cannabinoid Receptor Involvement by Braida D, Limonta V, Pegorini S, Zani A, Guerini-Rocco C, Gori E, Sala M. Psychopharmacology. 190(4): 441–448 (2007).

Ethnopharmacognosy and Human Pharmacology of Salvia divinorum and Salvinorin A by Jonathan Ott. Curare. 18(1): 103-129 (1995).

Psychoactive Card IV. Salvia divinorum Epling et Játiva: Leaves of the Shepherdess by Jonathan Ott. Eleusis, n. 4, pp. 31-39, 1996.

Dose-Response Effects of Salvinorin A on Basal Dopamine Levels in the Caudate Putamen of C57BL/6J Mice by Zhang Y, Butelman ER, Schlussman SD, Ho A, Kreek MJ.

Effects of the Plant-Derived Hallucinogen Salvinorin A on Basal Dopamine Levels in the Caudate Putamen

and in a Conditioned Place Aversion Assay in Mice: Agonist Actions at Kappa Opioid Receptors Zhang et al. Psychopharmacology (Berl). 179(3): 551–558 (2005).

Pharmacological Characterization of the Novel Kappa Opioid Agonist Salvinorin A in the Mouse This study demonstrates that salvinorin A is active in vivo at kappa opioid receptors.

Use of Salvia divinorum, an Unscheduled Hallucinogenic Plant: A Web-Based Survey of 500 Users This survey characterized the reasons, methods, and reported consequences of Salvia divinorum use.

Pattern of Use and Subjective Effects of Salvia divinorum Among Recreational Users by González D, Riba J, Bouso JC, Gómez-Jarabo G, Barbanoj MJ. Drug and Alcohol Dependence. 85(2): 157–162 (2006).

Salvia divinorum–Prësenzeiner neuen Droge im Internet. Salvia divinorum—Representation of a New Drug in the Internet Abstract in English and German. Article in German only. by Siemann H, Specka M, Schifano F, Deluca P, Scherbaum N. Gesundheitswesen. 68(5): 323–327 (2006).

Salvia divinorum Epling et Játiva-M. (Labiatae): An Ethnopharmacological Investigation by Sherry A. Rovinsky. McNair Scholarly Review (1998).

Salvia divinorum: An Hallucinogenic Mint Which Might Become a New Recreational Drug in Switzerland Giroud et al. Forensic Science International. 112(2–3): 143–150 (2000).

Salvinorin: The Psychedelic Essence of Salvia divinorum An extraordinary book by D.M.Turner (1996).

The Mushrooms of Language by Henry Munn. This essay provides valuable insight into the Mazatec shamanic world.

NovaScreen® receptor selectivity report on salvinorin-A

"Sage Wisdom" An article from TRP Magazine

Cultivating Diviner's Sage by Will Beifuss (from TRP Magazine).

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